[HTML][HTML] A data-driven approach to decode metabolic dysfunction-associated steatotic liver disease

MJ Ramos, TJ Kendall, I Drozdov, JA Fallowfield - Annals of Hepatology, 2024 - Elsevier
Metabolic dysfunction-associated steatotic liver disease (MASLD), defined by the presence
of liver steatosis together with at least one out of five cardiometabolic factors, is the most …

[HTML][HTML] Machine Learning Enables Single-Score Assessment of MASLD Presence and Severity

R Chen, BO Petrazzini, G Nadkarni, G Rocheleau… - medRxiv, 2023 - ncbi.nlm.nih.gov
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects 30% of the global
population but is often underdiagnosed. To fill this diagnostic gap, we developed a digital …

[HTML][HTML] A natural language processing algorithm accurately classifies steatotic liver disease pathology to estimate the risk of cirrhosis

MS Sherman, PK Challa… - Hepatology …, 2024 - journals.lww.com
Background: Histopathology remains the gold standard for diagnosing and staging
metabolic dysfunction–associated steatotic liver disease (MASLD). The feasibility of studying …

[HTML][HTML] The gene expression signature of metabolic dysfunction-associated steatotic liver disease from a multiomics perspective

CJ Pirola, S Sookoian - Clinical and Molecular Hepatology, 2024 - ncbi.nlm.nih.gov
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and its severe clinical
form, metabolic dysfunctionassociated steatohepatitis (MASH), are chronic liver diseases …

[HTML][HTML] Identification of signature gene set as highly accurate determination of metabolic dysfunction-associated steatotic liver disease progression

S Oh, YH Baek, S Jung, S Yoon, B Kang… - Clinical and …, 2024 - ncbi.nlm.nih.gov
Methods Biopsy-tissue and blood samples from patients with 134 MASLD, comprising 60
steatosis and 74 MASH patients were performed omics analysis. SVM learning algorithm …

Liver-Quant: Feature-Based Image Analysis Toolkit for Automatic Quantification of Metabolic Dysfunction-Associated Steatotic Liver Disease

M Farzi, C McGenity, A Cratchley, L Leplat… - medRxiv, 2024 - medrxiv.org
Introduction: The histological assessment of liver biopsies by pathologists serves as the gold
standard for diagnosing metabolic dysfunction-associated steatotic liver disease (MASLD) …

[HTML][HTML] Omics-based biomarkers as useful tools in metabolic dysfunction-associated steatotic liver disease clinical practice: How far are we?

J Trinks, MF Mascardi, A Gadano… - World Journal of …, 2024 - ncbi.nlm.nih.gov
Unmet needs exist in metabolic dysfunction-associated steatotic liver disease (MASLD) risk
stratification. Our ability to identify patients with MASLD with advanced fibrosis and at higher …

Machine learning approaches to enhance diagnosis and staging of patients with MASLD using routinely available clinical information

M McTeer, D Applegate, P Mesenbrink, V Ratziu… - Plos one, 2024 - journals.plos.org
Aims Metabolic dysfunction Associated Steatotic Liver Disease (MASLD) outcomes such as
MASH (metabolic dysfunction associated steatohepatitis), fibrosis and cirrhosis are …

[HTML][HTML] Accurate prediction of all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease using electronic health records

I Drozdov, B Szubert, IA Rowe, TJ Kendall… - Annals of …, 2024 - Elsevier
Abstract Introduction and Objectives Despite the huge clinical burden of MASLD, validated
tools for early risk stratification are lacking, and heterogeneous disease expression and a …

Machine learning across multiple imaging and biomarker modalities in the UK Biobank improves genetic discovery for liver fat accumulation

H Somineni, S Mukherjee, D Amar, J Pei, K Guo… - medRxiv, 2024 - medrxiv.org
Metabolic dysfunction-associated steatotic liver disease (MASLD), liver with more than 5.5%
fat content, is a leading risk factor for chronic liver disease with an estimated worldwide …