Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia

H El Hajj, A Bazarbachi - Frontiers in Immunology, 2022 - frontiersin.org
The Human T-cell Leukemia virus type 1 (HTLV-1) causes an array of pathologies, the most
aggressive of which is adult T-cell leukemia (ATL), a fatal blood malignancy with dismal …

The roles of acquired and innate immunity in human T-cell leukemia virus type 1-mediated diseases

M Kannagi, A Hasegawa, A Takamori… - Frontiers in …, 2012 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and HTLV-
1-associated myelopathy/tropical spastic paraparesis in small subsets of HTLV-1 carriers …

Impact of host immunity on HTLV-1 pathogenesis: potential of Tax-targeted immunotherapy against ATL

M Kannagi, A Hasegawa, Y Nagano, S Kimpara… - Retrovirology, 2019 - Springer
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL),
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and other …

Strategies of human T-cell leukemia virus Type 1 for persistent infection: Implications for leukemogenesis of adult T-cell leukemia-lymphoma

J Yasunaga - Frontiers in microbiology, 2020 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) establishes persistent infection in vivo in two
distinct ways: de novo infection and clonal proliferation of infected cells. Two viral genes …

HTLV-1 Tax Tug-of-War: Cellular Senescence and Death or Cellular Transformation

M Bellon, C Nicot - Pathogens, 2024 - mdpi.com
Human T cell leukemia virus type 1 (HTLV-1) is a retrovirus associated with a
lymphoproliferative disease known as adult T cell leukemia/lymphoma (ATLL). HTLV-1 …

Mechanisms of oncogenesis by HTLV-1 Tax

S Mohanty, EW Harhaj - Pathogens, 2020 - mdpi.com
The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATLL), a neoplasm of CD4+ CD25+ T cells that occurs in 2–5% of …

Mouse models that enhanced our understanding of adult T cell leukemia

S Moodad, A Akkouche, R Hleihel… - Frontiers in …, 2018 - frontiersin.org
Adult T cell Leukemia (ATL) is an aggressive lymphoproliferative malignancy secondary to
infection by the human T-cell leukemia virus type I (HTLV-I) and is associated with a dismal …

Human T-Cell Leukemia Virus Type 1 Oncogenesis between Active Expression and Latency: A Possible Source for the Development of Therapeutic Targets

F Marino-Merlo, S Grelli, A Mastino, M Lai… - International Journal of …, 2023 - mdpi.com
The human T-cell leukemia virus type 1 (HTLV-1) is the only known human oncogenic
retrovirus. HTLV-1 can cause a type of cancer called adult T-cell leukemia/lymphoma (ATL) …

Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)

S Ahmadi Ghezeldasht, DJ Blackbourn… - Critical Reviews in …, 2023 - Taylor & Francis
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T
lymphocytes caused by human T lymphotropic virus type-1 (HTLV-1) infection. HTLV-1 was …

HTLV-1 HBZ viral protein: a key player in HTLV-1 mediated diseases

M Baratella, G Forlani, RS Accolla - Frontiers in microbiology, 2017 - frontiersin.org
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus that has
infected 10–15 million people worldwide. After a long latency, 3–5% of infected individuals …