Maternal diabetes is associated with increased transport of lipids to the fetus and increased
risk of hypertrophic cardiomyopathy in the fetus. During fetal life, the heart normally has …

Background: Children born to diabetic or obese mothers have a higher risk of heart disease
at birth and later in life. Using chromatin immunoprecipitation sequencing, we previously …

Obesity in pregnant women causes fetal cardiac dysfunction and increases offspring
cardiovascular disease risk, but its effect on myocardial metabolism is unknown. We …

Maternal obesity during pregnancy has immediate and long-term detrimental effects on the
offspring heart. In this study, we characterized the cardiac and circulatory lipid profiles in late …

Aims/hypothesis The impact of diabetic pregnancy has been investigated extensively
regarding offspring metabolism; however, little is known about the influence on the heart. We …

Maternal diabetes mellitus is associated with increased teratogenesis, which can occur in
pregestational type 1 and type 2 diabetes. Cardiac defects and with neural tube defects are …

Congenital heart disease (CHD) is the leading cause of birth defect‐related death in infants
and is a global pediatric health concern. While the genetic causes of CHD have become …

Human and animal studies suggest that suboptimal early nutrition during critical
developmental periods impacts long-term health. For example, maternal overnutrition during …

According to the “developmental origin of health and disease” hypothesis, the metabolic set
points of glucose and lipid metabolism are determined prenatally. In the case of a diabetic …

Offspring of diabetic pregnancies are at risk of cardiovascular disease at birth and
throughout life, purportedly through fuel-mediated influences on the developing heart …