It is generally agreed that the nuclei of eukaryotic cells at interphase are partitioned into
disjointed territories, with distinct regions occupied by certain chromosomes. However, the …

During interphase chromosomes decondense, but fluorescent in situ hybridization
experiments reveal the existence of distinct territories occupied by individual chromosomes …

We investigate chromosome organization within the nucleus using polymer models whose
formulation is closely guided by experiments in live yeast cells. We employ bead-spring …

Within the confines of a densely populated cell nucleus, chromatin undergoes intricate
folding, forming loops, domains, and compartments under the governance of topological …

Polymer models tied together by constraints of looping and confinement have been used to
explain many of the observed organizational characteristics of interphase chromosomes …

Polymer physics simulations have provided a versatile framework to quantitatively explore
the complex mechanisms driving chromosome organization. However, simulating whole …

The 3D organization of eukaryotic genomes plays an important role in genome function.
While significant progress has been made in deciphering the folding mechanisms of …

Recent investigations have shown that isochores are characterized by a 3-D structure which
is primarily responsible for the topology of chromatin domains. More precisely, an analysis of …

Topological constraints can affect both equilibrium and dynamic properties of polymer
systems and can play a role in the organization of chromosomes. Despite many theoretical …

Chromosomes are exceedingly long topologically constrained polymers compacted in a cell
nucleus. We recently suggested that chromosomes are organized into loops by an active …