[HTML][HTML] Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection

Q Geng, W Tai, VK Baxter, J Shi, Y Wan, X Zhang… - PLoS …, 2021 - journals.plos.org
The key to battling the COVID-19 pandemic and its potential aftermath is to develop a variety
of vaccines that are efficacious and safe, elicit lasting immunity, and cover a range of SARS …

[HTML][HTML] Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines

TH Dickey, R Ma, S Orr-Gonzalez, T Ouahes, P Patel… - Cell reports, 2023 - cell.com
Waning immunity and emerging variants necessitate continued vaccination against severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Improvements in vaccine safety …

[HTML][HTML] Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization

S Chiba, SJ Frey, PJ Halfmann, M Kuroda… - Communications …, 2021 - nature.com
The COVID-19 pandemic continues to wreak havoc as worldwide SARS-CoV-2 infection,
hospitalization, and death rates climb unabated. Effective vaccines remain the most …

[HTML][HTML] Nanoparticle vaccines based on the receptor binding domain (RBD) and heptad repeat (HR) of SARS-CoV-2 elicit robust protective immune responses

X Ma, F Zou, F Yu, R Li, Y Yuan, Y Zhang, X Zhang… - Immunity, 2020 - cell.com
Various vaccine strategies have been proposed in response to the global COVID-19
pandemic, each with unique strategies for eliciting immune responses. Here, we developed …

[HTML][HTML] Nanoparticle and virus-like particle vaccine approaches against SARS-CoV-2

C Kim, JD Kim, SU Seo - Journal of Microbiology, 2022 - Springer
The global spread of coronavirus disease 2019 caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has provoked an urgent need for …

Development of receptor binding domain (RBD)‐conjugated nanoparticle vaccines with broad neutralization against SARS‐CoV‐2 delta and other variants

R Chen, X Zhang, Y Yuan, X Deng, B Wu… - Advanced …, 2022 - Wiley Online Library
Abstract The SARS‐CoV‐2 Delta (B. 1.617. 2) strain is a variant of concern (VOC) that has
become the dominant strain worldwide in 2021. Its transmission capacity is approximately …

Two-component nanoparticle vaccine displaying glycosylated spike S1 domain induces neutralizing antibody response against SARS-CoV-2 variants

L van Oosten, JJ Altenburg, C Fougeroux… - MBio, 2021 - Am Soc Microbiol
Vaccines pave the way out of the SARS-CoV-2 pandemic. Besides mRNA and adenoviral
vector vaccines, effective protein-based vaccines are needed for immunization against …

[HTML][HTML] Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

AC Walls, MC Miranda, A Schäfer, MN Pham… - Cell, 2021 - cell.com
Understanding vaccine-elicited protection against SARS-CoV-2 variants and other
sarbecoviruses is key for guiding public health policies. We show that a clinical stage …

[HTML][HTML] Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

AC Walls, B Fiala, A Schäfer, S Wrenn, MN Pham… - Cell, 2020 - cell.com
A safe, effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2
pandemic. We describe the structure-based design of self-assembling protein nanoparticle …

A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross‐Protection Activity against Multiple SARS‐CoV‐2 Sublineages

X Zhang, S Wu, J Liu, R Chen, Y Zhang, Y Lin… - Advanced …, 2023 - Wiley Online Library
Because of the rapid mutation and high airborne transmission of SARS‐CoV‐2, a universal
vaccine preventing the infection in the upper respiratory tract is particularly urgent. Here, a …