[HTML][HTML] Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection
The key to battling the COVID-19 pandemic and its potential aftermath is to develop a variety
of vaccines that are efficacious and safe, elicit lasting immunity, and cover a range of SARS …
of vaccines that are efficacious and safe, elicit lasting immunity, and cover a range of SARS …
[HTML][HTML] Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines
Waning immunity and emerging variants necessitate continued vaccination against severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Improvements in vaccine safety …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Improvements in vaccine safety …
[HTML][HTML] Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization
S Chiba, SJ Frey, PJ Halfmann, M Kuroda… - Communications …, 2021 - nature.com
The COVID-19 pandemic continues to wreak havoc as worldwide SARS-CoV-2 infection,
hospitalization, and death rates climb unabated. Effective vaccines remain the most …
hospitalization, and death rates climb unabated. Effective vaccines remain the most …
[HTML][HTML] Nanoparticle vaccines based on the receptor binding domain (RBD) and heptad repeat (HR) of SARS-CoV-2 elicit robust protective immune responses
Various vaccine strategies have been proposed in response to the global COVID-19
pandemic, each with unique strategies for eliciting immune responses. Here, we developed …
pandemic, each with unique strategies for eliciting immune responses. Here, we developed …
[HTML][HTML] Nanoparticle and virus-like particle vaccine approaches against SARS-CoV-2
C Kim, JD Kim, SU Seo - Journal of Microbiology, 2022 - Springer
The global spread of coronavirus disease 2019 caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has provoked an urgent need for …
syndrome coronavirus 2 (SARS-CoV-2) infection has provoked an urgent need for …
Development of receptor binding domain (RBD)‐conjugated nanoparticle vaccines with broad neutralization against SARS‐CoV‐2 delta and other variants
R Chen, X Zhang, Y Yuan, X Deng, B Wu… - Advanced …, 2022 - Wiley Online Library
Abstract The SARS‐CoV‐2 Delta (B. 1.617. 2) strain is a variant of concern (VOC) that has
become the dominant strain worldwide in 2021. Its transmission capacity is approximately …
become the dominant strain worldwide in 2021. Its transmission capacity is approximately …
Two-component nanoparticle vaccine displaying glycosylated spike S1 domain induces neutralizing antibody response against SARS-CoV-2 variants
L van Oosten, JJ Altenburg, C Fougeroux… - MBio, 2021 - Am Soc Microbiol
Vaccines pave the way out of the SARS-CoV-2 pandemic. Besides mRNA and adenoviral
vector vaccines, effective protein-based vaccines are needed for immunization against …
vector vaccines, effective protein-based vaccines are needed for immunization against …
[HTML][HTML] Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines
Understanding vaccine-elicited protection against SARS-CoV-2 variants and other
sarbecoviruses is key for guiding public health policies. We show that a clinical stage …
sarbecoviruses is key for guiding public health policies. We show that a clinical stage …
[HTML][HTML] Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2
A safe, effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2
pandemic. We describe the structure-based design of self-assembling protein nanoparticle …
pandemic. We describe the structure-based design of self-assembling protein nanoparticle …
A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross‐Protection Activity against Multiple SARS‐CoV‐2 Sublineages
X Zhang, S Wu, J Liu, R Chen, Y Zhang, Y Lin… - Advanced …, 2023 - Wiley Online Library
Because of the rapid mutation and high airborne transmission of SARS‐CoV‐2, a universal
vaccine preventing the infection in the upper respiratory tract is particularly urgent. Here, a …
vaccine preventing the infection in the upper respiratory tract is particularly urgent. Here, a …
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