Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions
Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain
poorly understood. We analyze several thousand plasma proteins longitudinally in 306 …
poorly understood. We analyze several thousand plasma proteins longitudinally in 306 …
Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19
L Haljasmägi, A Salumets, AP Rumm, M Jürgenson… - Scientific reports, 2020 - nature.com
SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease.
Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying …
Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying …
A time-resolved proteomic and prognostic map of COVID-19
V Demichev, P Tober-Lau, O Lemke, T Nazarenko… - Cell systems, 2021 - cell.com
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection
to severe organ damage and death. We characterized the time-dependent progression of …
to severe organ damage and death. We characterized the time-dependent progression of …
Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors
X Gu, S Wang, W Zhang, C Li, L Guo, Z Wang, H Li… - …, 2023 - thelancet.com
Background As a debilitating condition that can impact a whole spectrum of people and
involve multi-organ systems, long COVID has aroused the most attention than ever …
involve multi-organ systems, long COVID has aroused the most attention than ever …
Plasma proteomics identify biomarkers and pathogenesis of COVID-19
T Shu, W Ning, D Wu, J Xu, Q Han, M Huang, X Zou… - Immunity, 2020 - cell.com
Summary The coronavirus disease 2019 (COVID-19) pandemic is a global public health
crisis. However, little is known about the pathogenesis and biomarkers of COVID-19. Here …
crisis. However, little is known about the pathogenesis and biomarkers of COVID-19. Here …
System-wide transcriptome damage and tissue identity loss in COVID-19 patients
The molecular mechanisms underlying the clinical manifestations of coronavirus disease
2019 (COVID-19), and what distinguishes them from common seasonal influenza virus and …
2019 (COVID-19), and what distinguishes them from common seasonal influenza virus and …
[HTML][HTML] Large-scale multi-omic analysis of COVID-19 severity
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …
A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients
COVID-19 patients show heterogeneity in clinical presentation and outcomes that makes
pandemic control and strategy difficult; optimizing management requires a systems biology …
pandemic control and strategy difficult; optimizing management requires a systems biology …
Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications
MAY Al-Nesf, HB Abdesselem, I Bensmail… - Nature …, 2022 - nature.com
COVID-19 complications still present a huge burden on healthcare systems and warrant
predictive risk models to triage patients and inform early intervention. Here, we profile 893 …
predictive risk models to triage patients and inform early intervention. Here, we profile 893 …
Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia
Background COVID-19 remains a major public health challenge, requiring the development
of tools to improve diagnosis and inform therapeutic decisions. As dysregulated …
of tools to improve diagnosis and inform therapeutic decisions. As dysregulated …