Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized
by the inflammation of the bone leading to degeneration and loss of cartilage function …

Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of
articular cartilage. Although disease initiation may be multi‐factorial, the cartilage …

Summary Introduction Matrix metalloproteinases (MMPs) and 'aggrecanase'a disintegrin
and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play …

The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family
consists of 19 proteases. These enzymes are known to play important roles in development …

Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)
family are known to influence development, angiogenesis, coagulation and progression of …

Destruction of articular cartilage is a key feature of a number of arthritides, osteoarthritis
prominent among them. Aggrecan degradation, caused by increased activity of proteolytic …

The ADAMTS proteinases are a group of multidomain and secreted metalloproteinases
containing the thrombospondin motifs. ADAMTS‐7 is a member of ADAMTS family and plays …

The ADAMTSs (ad isintegrin a nd m etalloproteinase with t hrombo s pondin motifs) are a
group of proteases that are found both in mammals and invertebrates. Since the prototype …

Osteoarthritis is characterized by the loss of aggrecan and collagen from the cartilage
extracellular matrix. The proteinases responsible for the breakdown of cartilage aggrecan …

Aggrecanases have been characterized as proteinases that cleave the Glu 373-Ala 374
bond of the aggrecan core protein, and they are multidomain metalloproteinases belonging …