With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …

Alzheimer's disease (AD) is a complex neurodegenerative disorder with a multi-faceted
pathogenesis. So far, the therapeutic paradigm “one-compound-one-target” has failed and …

Among the various drug discovery methods, a very promising modern approach consists in
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major
cause of death worldwide. The number of people suffering from this debilitating disorder is …

Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …

Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder.
Currently, no effective treatment is available and this is due to multiple factors involved in …

The discovery and development of multitarget-directed ligands (MTDLs) is a promising
strategy to find new therapeutic solutions for neurodegenerative diseases (NDs), in …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that eventually leads
to dementia and death of the patient. Despite the enormous amounts of resources and …

The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …