Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …
an overwhelming health, social, economic, and political problem to nations. Unless a new …
Multi-target directed drugs: a modern approach for design of new drugs for the treatment of Alzheimer's disease
K Simone Tranches Dias… - Current …, 2014 - ingentaconnect.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder with a multi-faceted
pathogenesis. So far, the therapeutic paradigm “one-compound-one-target” has failed and …
pathogenesis. So far, the therapeutic paradigm “one-compound-one-target” has failed and …
Multi-target-directed ligands in Alzheimer's disease treatment
M Bajda, N Guzior, M Ignasik… - Current medicinal …, 2011 - ingentaconnect.com
Among the various drug discovery methods, a very promising modern approach consists in
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …
Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands
L Blaikie, G Kay, PKT Lin - MedChemComm, 2019 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major
cause of death worldwide. The number of people suffering from this debilitating disorder is …
cause of death worldwide. The number of people suffering from this debilitating disorder is …
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
Perspectives for new and more efficient multifunctional ligands for Alzheimer′ s disease therapy
A Zagórska, A Jaromin - Molecules, 2020 - mdpi.com
Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …
Multi-target directed drugs as a modern approach for drug design towards Alzheimer's disease: an update
M de Freitas Silva, KST Dias, VS Gontijo… - Current Medicinal …, 2018 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder.
Currently, no effective treatment is available and this is due to multiple factors involved in …
Currently, no effective treatment is available and this is due to multiple factors involved in …
The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease
The discovery and development of multitarget-directed ligands (MTDLs) is a promising
strategy to find new therapeutic solutions for neurodegenerative diseases (NDs), in …
strategy to find new therapeutic solutions for neurodegenerative diseases (NDs), in …
Multi-targets: An unconventional drug development strategy for Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that eventually leads
to dementia and death of the patient. Despite the enormous amounts of resources and …
to dementia and death of the patient. Despite the enormous amounts of resources and …
Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for Alzheimer's disease
A Agis-Torres, M Sollhuber… - Current …, 2014 - ingentaconnect.com
The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …
continuous growing amount of papers and reviews, reflecting the important efforts made by …