Specialized connective tissues, including bone and adipose tissues, control various
physiological activities, including mineral and energy homeostasis. However, the identity of …

We have previously shown that the retinoblastoma protein (pRb) can activate expression of
Runx2-dependent, bone-specific genes in cultured cells. We now show that pRb also plays …

Abstract Polycomb repressive complex 2 (PRC2) controls maintenance and lineage
determination of stem cells by suppressing genes that regulate cellular differentiation and …

Post-natal skeletal stem cells expressing PRX1 (pnPRX1+) have been identified in the
calvaria and in the axial skeleton. Here we characterize the location and functional capacity …

Differentiation of adipocytes from preadipocytes contributes to adipose tissue expansion in
obesity. Impaired adipogenesis may underlie the development of metabolic diseases such …

Leptin receptor (LepR)‐positive cells are key components of the bone marrow hematopoietic
microenvironment, and highly enrich skeletal stem and progenitor cells that maintain …

Healthy adipose tissue remodeling depends on the balance between de novo adipogenesis
from adipogenic progenitor cells and the hypertrophy of adipocytes. De novo adipogenesis …

Bones consist of a number of cell types including osteoblasts and their precursor cells at
various stages of differentiation. To analyze cellular organization within the bone, we …

The four R-spondin secreted ligands (RSPO1–RSPO4) act via their cognate LGR4, LGR5
and LGR6 receptors to amplify WNT signalling,–. Here we report an allelic series of …

Polycomb repressive complexes (PRCs) 1 and 2 are essential chromatin regulators of cell
identity. PRC1, a dominant executer of Polycomb-mediated control, functions as multiple sub …