This guidance endeavours to articulate the scientific evidence underpinning the clinical
utility of polygenic risk score in stratifying breast cancer risk, with a particular emphasis on …

Polygenic risk scores (PRSs) have been consistently associated with elevated breast cancer
risk in cohort studies and are associated with risk in both women with and those without a …

Cancer genomic medicine has until now focused largely on high risk, rare genetic variants.
However, common variants in aggregate can contribute significantly to the risk for cancers …

Despite screening programmes, numerous clinical studies and new breast imaging
techniques, breast cancer incidence for women continues to rise. The arrival of predictive …

Polygenic factors are estimated to account for an additional 18% of the familial relative risk
of breast cancer, with those at the highest level of polygenic risk distribution having a least a …

1508 Background: While assessment of genetic contribution to breast cancer (BC) risk was
once limited to high-penetrance genes such as BRCA1/2, additional genes conferring two-to …

Abstract Background The Breast and Ovarian Analysis of Disease Incidence and Carrier
Estimation Algorithm and the International Breast Cancer Intervention Study breast cancer …

In this issue of the Journal, Shieh et al. report findings from an assessment of performance of
a polygenic risk score (PRS) for breast cancer in Latin American women (Latinas)(1). Study …

The use of a polygenic risk score (PRS) as an independent risk factor for common diseases
is becoming mainstream. 1–3 The initial hype on their clinical applicability appears to be …

Abstract Polygenic Risk Scores (PRS) are a major component of accurate breast cancer risk
prediction and have the potential to improve screening and prevention strategies. PRS …