The Hepatocyte growth factor (HGF)—mesenchymal-epithelial transition (MET) pathway is
deregulated in several cancers and is associated with aggressive phenotype and worse …

The hepatocyte growth factor (HGF)–mesenchymal-epithelial transition factor (MET)
pathway has a key role in carcinogenesis; it is implicated in proliferation, inhibition of …

Among hundreds of thousands of signal receptors contributing to oncogenic activation,
tumorigenesis, and metastasis, the hepatocyte growth factor (HGF) receptor–also called …

Targeted therapies have opened new perspectives in clinical oncology. However, clinicians
have observed a lack of response in a relevant percentage of patients and frequent relapse …

The tumor microenvironment plays a key role in tumor development and progression.
Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which …

Hepatocyte growth factor (HGF) is the ligand for the tyrosine kinase receptor c-Met
(Mesenchymal Epithelial Transition Factor also known as Hepatocyte Growth Factor …

The hepatocyte growth factor/mesenchymal-epithelial transition factor (HGF/c-MET) receptor
tyrosine kinase (RTK) pathway plays a pleotropic role in cell proliferation, migration …

MET is a tyrosine kinase receptor that, upon binding of its natural ligand, the hepatocyte
growth factor (HGF), is phosphorylated and subsequently activates different signalling …

Hepatocyte growth factor (HGF)-induced activation of its cell surface receptor, the Met
tyrosine kinase, drives mitogenesis, motogenesis and morphogenesis in a wide spectrum of …

Introduction: Under normal conditions, hepatocyte growth factor (HGF)-induced activation of
its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand …