Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …

Cyclooxygenases play a vital role in inflammation and are responsible for the production of
prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and …

The two isoforms of enzyme cyclooxygenase viz. COX-1 and COX-2 play key roles in the
metabolism of arachidonic acid. The enzyme COX-2, when over expressed, leads to more …

Cyclooxygenase (COX) enzymes comprise COX-1 and COX-2 isoforms and are responsible
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …

Since cyclooxygenase (COX) isozymes discovery, many papers and reviews have been
published to describe the structural bases of COX inhibition, and to debate on the …

Abstract Selective cyclooxygenase-2 (COX-2) inhibitors have exhibited notable medicinal
importance. In recent years, the discovery of new anti-inflammatory agents as selective COX …

New arylhydrazone derivatives and a series of 1, 5-diphenyl pyrazoles were designed and
synthesized from 1-(4-chlorophenyl)-4, 4, 4-trifuorobutane-1, 3-dione 1. The newly …

The non-steroidal anti-inflammatory drugs (NSAIDs) are diverse group of compounds used
for the treatment of inflammation, since the introduction of acetylsalicylic acid in 1899 …

The recent marketing of two selective cyclooxygenase-2 (COX-2) inhibitors, celecoxib and
rofecoxib is remarkable considering that COX-2 was only discovered eight years ago as a …

COX-2, a key enzyme that catalyzed the rate-limiting steps in the conversion of arachidonic
acid to prostaglandins, played a pivotal role in the inflammatory process. Different from other …