Molecular mechanism of tanshinone against prostate cancer

W Li, T Huang, S Xu, B Che, Y Yu, W Zhang, K Tang - Molecules, 2022 - mdpi.com
Prostate cancer (PCa) is the most common malignant tumor of the male urinary system in
Europe and America. According to the data in the World Cancer Report 2020, the incidence …

A novel tanshinone analog exerts anti-cancer effects in prostate cancer by inducing cell apoptosis, arresting cell cycle at G2 phase and blocking metastatic ability

M Wang, X Zeng, S Li, Z Sun, J Yu, C Chen… - International Journal of …, 2019 - mdpi.com
Prostate cancer (PCa), an epithelial malignant tumor, is the second common cause of
cancer death among males in western countries. Thus, the development of new strategies is …

[HTML][HTML] Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of …

CY Wu, YH Yang, YY Lin, FC Kuan, YS Lin, WY Lin… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Danshen (Salvia miltiorrhiza Bunge) is widely used in traditional Chinese medicine.
In our study, the in vivo protective effect of danshen in prostate cancer patients was validated …

Tanshinones from Chinese Medicinal Herb Danshen (Salvia miltiorrhiza Bunge) Suppress Prostate Cancer Growth and Androgen Receptor Signaling

Y Zhang, SH Won, C Jiang, HJ Lee, SJ Jeong… - Pharmaceutical …, 2012 - Springer
Purpose To test whether tanshinones inhibit prostate cancer (PCa) growth at least in part
through inhibiting androgen receptor (AR) signaling. Methods We evaluated cell growth …

The mechanisms of tanshinone in the treatment of tumors

P Zhang, W Liu, Y Wang - Frontiers in Pharmacology, 2023 - frontiersin.org
Tanshinone is a lipophilic compound that is present in traditional Chinese medicine and is
derived from the roots of Salvia miltiorrhiza (Danshen). It has been proven to be highly …

Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice

Y Gong, Y Li, Y Lu, L Li, H Abdolmaleky… - … journal of cancer, 2011 - Wiley Online Library
Searching for efficacious and safe agents for the chemoprevention and therapy of prostate
cancer has become the top priority of research. The objective of this study was to determine …

Synergistic antitumor effects of tanshinone II A in combination with cisplatin via apoptosis in the prostate cancer cells

LL Hou, QJ Xu, GQ Hu, SQ Xie - Yao xue xue bao= Acta …, 2013 - europepmc.org
Treatment with the combination of Chinese herbs and cytotoxic chemotherapies showed a
higher survival rate in clinical trials. In this report, the results demonstrated that the …

Shikonin inhibits the growth of human prostate cancer cells via modulation of the androgen receptor

SY Jang, EH Jang, SY Jeong… - … Journal of Oncology, 2014 - spandidos-publications.com
Shikonin, a natural naphthoquinone isolated from the traditional Chinese medicine Zi Cao
(gromwell), has been shown to possess tumor cell killing activity. The human androgen …

Tanshinone IIA inhibits human prostate cancer cells growth by induction of endoplasmic reticulum stress in vitro and in vivo

SC Chiu, SY Huang, SP Chen, CC Su… - Prostate cancer and …, 2013 - nature.com
BACKGROUND: Tanshinone IIA (Tan-IIA) is one of the major lipophilic components isolated
from the root of Salviae Miltiorrhizae Radix. We explored the mechanisms of cell death …

Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast cancer cell lines Retraction in/10.3892/mmr. 2021.12080

L Wang, J Wu, J Lu, R Ma… - Molecular medicine …, 2015 - spandidos-publications.com
Breast cancer is the second leading cause of cancer‑related mortality in females worldwide.
Therefore, identifying alternative strategies to combat the disease mortality is important. The …