Pattern separation (PS) dysfunction is a type of cognitive impairment that presents early
during the aging process, and this deficit has been attributed to structural and functional …

Aims Synaptic dysfunction is a hallmark pathology of Alzheimer's disease (AD) and is
strongly associated with cognitive impairment. Abnormal phagocytosis by the microglia is …

Abstract Absent in melanoma 2 (AIM2) senses damaged-associated molecular patterns
(DAMPs) and recruits apoptosis speck-like protein (ASC) and caspase-1 to form a molecular …

Objective: Inflammation is clearly associated with Alzheimer disease (AD). Knockout of
Nlrp3, a gene encoding an inflammasome sensor, has been shown to ameliorate AD …

Cumulative evidence indicates that activation of innate immune responses in the central
nervous system (CNS) induces the expression of type 1 interferons (T1 IFNs), a family of …

In traumatic brain injury, absent in melanoma 2 (AIM2) has been demonstrated to be
involved in pyroptotic neuronal cell death. Although the pathophysiological mechanism of …

Chronic cerebral hypoperfusion is associated with vascular dementia (VaD). Cerebral
hypoperfusion may initiate complex molecular and cellular inflammatory pathways that …

Although over one-third of stroke patients may develop post-stroke cognitive impairment
(PSCI), the mechanisms underlying PSCI remain unclear. We explored here, the …

As a double-stranded DNA (dsDNA) sensor, the PYHIN family member absent in melanoma
2 (AIM2) is an essential component of the inflammasome families. Activation of AIM2 by …

Inflammasome involvement in Parkinson's disease (PD) has been intensively investigated.
Absent in melanoma 2 (AIM2) is an essential inflammasome protein known to contribute to …