New therapies that promote antitumour immunity have been recently developed. Most of
these immunomodulatory approaches have focused on enhancing T-cell responses, either …

A pre-existing T cell-inflamed tumor microenvironment has prognostic utility and also can be
predictive for response to contemporary cancer immunotherapies. The generation of a …

Activating the immune system for therapeutic benefit in cancer has long been a goal in
immunology and oncology. After decades of disappointment, the tide has finally changed …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Over the past 25 years, research in cancer therapeutics has largely focused on two distinct
lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous …

Immunotherapies that enhance the ability of the immune system to target cancer cells have
proven effective in a variety of tumor types, yet clinical responses vary across patients and …

The ability of the immune system to eliminate and shape the immunogenicity of tumours
defines the process of cancer immunoediting. Immunotherapies such as those that target …

Despite major advances in our understanding of adaptive immunity and dendritic cells,
consistent and durable responses to cancer vaccines remain elusive and active …

Antitumour immunity gets a boost | Nature Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …

Recent clinical trials using immunotherapy have demonstrated its potential to control cancer
by disinhibiting the immune system. Immune checkpoint blocking (ICB) antibodies against …