Harnessing innate immunity in cancer therapy
New therapies that promote antitumour immunity have been recently developed. Most of
these immunomodulatory approaches have focused on enhancing T-cell responses, either …
these immunomodulatory approaches have focused on enhancing T-cell responses, either …
Cancer immunotherapy comes of age
Activating the immune system for therapeutic benefit in cancer has long been a goal in
immunology and oncology. After decades of disappointment, the tide has finally changed …
immunology and oncology. After decades of disappointment, the tide has finally changed …
Innate immune signaling and regulation in cancer immunotherapy
L Corrales, V Matson, B Flood, S Spranger… - Cell research, 2017 - nature.com
A pre-existing T cell-inflamed tumor microenvironment has prognostic utility and also can be
predictive for response to contemporary cancer immunotherapies. The generation of a …
predictive for response to contemporary cancer immunotherapies. The generation of a …
Exploiting innate immunity for cancer immunotherapy
M Yi, T Li, M Niu, Q Mei, B Zhao, Q Chu, Z Dai, K Wu - Molecular cancer, 2023 - Springer
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …
However, most of these immunomodulatory strategies focus on harnessing adaptive …
Prospects for combining targeted and conventional cancer therapy with immunotherapy
P Gotwals, S Cameron, D Cipolletta… - Nature Reviews …, 2017 - nature.com
Over the past 25 years, research in cancer therapeutics has largely focused on two distinct
lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous …
lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous …
Recruiting T cells in cancer immunotherapy
Immunotherapies that enhance the ability of the immune system to target cancer cells have
proven effective in a variety of tumor types, yet clinical responses vary across patients and …
proven effective in a variety of tumor types, yet clinical responses vary across patients and …
MHC-II neoantigens shape tumour immunity and response to immunotherapy
E Alspach, DM Lussier, AP Miceli, I Kizhvatov… - Nature, 2019 - nature.com
The ability of the immune system to eliminate and shape the immunogenicity of tumours
defines the process of cancer immunoediting. Immunotherapies such as those that target …
defines the process of cancer immunoediting. Immunotherapies such as those that target …
A fresh look at tumor immunosurveillance and immunotherapy
MJ Smyth, DI Godfrey, JA Trapani - Nature immunology, 2001 - nature.com
Despite major advances in our understanding of adaptive immunity and dendritic cells,
consistent and durable responses to cancer vaccines remain elusive and active …
consistent and durable responses to cancer vaccines remain elusive and active …
Antitumour immunity gets a boost
JD Wolchok, TA Chan - Nature, 2014 - nature.com
Antitumour immunity gets a boost | Nature Skip to main content Thank you for visiting nature.com.
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Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells
O De Henau, M Rausch, D Winkler, LF Campesato… - Nature, 2016 - nature.com
Recent clinical trials using immunotherapy have demonstrated its potential to control cancer
by disinhibiting the immune system. Immune checkpoint blocking (ICB) antibodies against …
by disinhibiting the immune system. Immune checkpoint blocking (ICB) antibodies against …