The role of vitamin D in autoimmune diseases: could sex make the difference?

ML Dupuis, MT Pagano, M Pierdominici… - Biology of sex …, 2021 - Springer
Over the last decades, a central role for vitamin D in immune modulation has been well
established. The active form of vitamin D, ie, 1, 25-dihydroxyvitamin D, through the …

Pathophysiological role and therapeutic implications of vitamin D in autoimmunity: focus on chronic autoimmune diseases

M Bellan, L Andreoli, C Mele, PP Sainaghi… - Nutrients, 2020 - mdpi.com
Vitamin D is a pleiotropic secosteroid yielding multiple actions in human physiology.
Besides the canonical regulatory activity on bone metabolism, several non-classical actions …

Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications

G Murdaca, A Tonacci, S Negrini, M Greco, M Borro… - Autoimmunity …, 2019 - Elsevier
Vitamin D plays a key role in in calcium homeostasis and, thus, provides an important
support in bone growth by aiding in the mineralization of the collagen matrix. However …

Vitamin D in autoimmune, infectious and allergic diseases: a vital player?

TL Van Belle, C Gysemans, C Mathieu - Best practice & research Clinical …, 2011 - Elsevier
Vitamin D is a steroid hormone that is acquired via diet or synthesized in the skin upon UV
exposure and needs subsequent hydroxylation steps to become activated as 1, 25 …

Vitamin D endocrine system involvement in autoimmune rheumatic diseases

M Cutolo, C Pizzorni, A Sulli - Autoimmunity reviews, 2011 - Elsevier
Vitamin D is synthesized from cholesterol in the skin (80–90%) under the sunlight and then
metabolized into an active D hormone in liver, kidney and peripheral immune/inflammatory …

Vitamin D in autoimmunity: molecular mechanisms and therapeutic potential

W Dankers, EM Colin, JP Van Hamburg… - Frontiers in …, 2017 - frontiersin.org
Over the last three decades, it has become clear that the role of vitamin D goes beyond the
regulation of calcium homeostasis and bone health. An important extraskeletal effect of …

Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept

B Altieri, G Muscogiuri, L Barrea, C Mathieu… - Reviews in Endocrine …, 2017 - Springer
In the last few years, more attention has been given to the “non-calcemic” effect of vitamin D.
Several observational studies and meta-analyses demonstrated an association between …

Vitamin D and autoimmune thyroid diseases: facts and unresolved questions

G Bizzaro, Y Shoenfeld - Immunologic research, 2015 - Springer
Vitamin D deficiency (levels lower than 20 ng/ml) is becoming a global health problem, since
it is increasingly represented even among healthy subjects. Vitamin D, as an environmental …

How does vitamin D affect immune cells crosstalk in autoimmune diseases?

D Gallo, D Baci, N Kustrimovic, N Lanzo… - International Journal of …, 2023 - mdpi.com
Vitamin D is a secosteroid hormone that is highly involved in bone health. Mounting
evidence revealed that, in addition to the regulation of mineral metabolism, vitamin D is …

Vitamin D in systemic and organ-specific autoimmune diseases

N Agmon-Levin, E Theodor, RM Segal… - Clinical reviews in allergy …, 2013 - Springer
Lately, vitamin D has been linked with metabolic and immunological processes, which
established its role as an essential component of human health preservation. Vitamin D has …