Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Aims: Cystathionine β-synthase (CBS) catalyzes the first and rate-limiting step in the two-
step trans-sulfuration pathway that converts homocysteine to cysteine. It is also one of three …

Background and Purpose Hydrogen sulfide (H2S) is a signalling molecule that belongs to
the gasotransmitter family. Two major sources for endogenous enzymatic production of H2S …

Cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) are two key enzymes
involved in the synthesis of hydrogen sulfide (H2S). CBS catalyzes the pyridoxal 5' …

Cystathionine β-synthase (CBS) is the first enzyme in the transsulfuration pathway,
catalyzing the conversion of serine and homocysteine to cystathionine and water. The …

Cystathionine β‐synthase (CBS) regulates homocysteine metabolism and contributes to
hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the …

Significance: Cancer represents a major socioeconomic problem; there is a significant need
for novel therapeutic approaches targeting tumor-specific pathways. Recent Advances: In …

The transsulfuration pathway is a metabolic pathway where transfer of sulfur from
homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur …

The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is
markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and …

CBS (cystathionine β-synthase) is a multidomain tetrameric enzyme essential in the
regulation of homocysteine metabolism, whose activity is enhanced by the allosteric …