Chemogenetic and optogenetic manipulations of microglia in chronic pain
S Parusel, MH Yi, CL Hunt, LJ Wu - Neuroscience Bulletin, 2023 - Springer
Chronic pain relief remains an unmet medical need. Current research points to a substantial
contribution of glia-neuron interaction in its pathogenesis. Particularly, microglia play a …
contribution of glia-neuron interaction in its pathogenesis. Particularly, microglia play a …
Microglia-mediated regulation of neuropathic pain: molecular and cellular mechanisms
M Tsuda - Biological and Pharmaceutical Bulletin, 2019 - jstage.jst.go.jp
Pain is a defense system that responds rapidly to harmful internal and external stimuli
through the somatosensory neuronal pathway. However, damage to the nervous system …
through the somatosensory neuronal pathway. However, damage to the nervous system …
Targeting the microglial signaling pathways: new insights in the modulation of neuropathic pain
K Popiolek-Barczyk, J Mika - Current Medicinal Chemistry, 2016 - ingentaconnect.com
The microglia, once thought only to be supporting cells of the central nervous system (CNS),
are now recognized to play essential roles in many pathologies. Many studies within the last …
are now recognized to play essential roles in many pathologies. Many studies within the last …
Microglial diversity in neuropathic pain
Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …
pathological contexts, including neuropathic pain, a chronic pain condition caused by …
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice
Microglia play an important role in the central sensitization and chronic pain. However, a
direct connection between microglial function and pain development in vivo remains …
direct connection between microglial function and pain development in vivo remains …
Special issue on microglia and chronic pain
CE Hulsebosch - Experimental neurology, 2012 - Elsevier
This special issue of Experimental Neurology is devoted to the role of Microglia and Chronic
Pain. Chronic pain affects 116 million people per year in the United States, which is more …
Pain. Chronic pain affects 116 million people per year in the United States, which is more …
[HTML][HTML] Central nervous system targets: glial cell mechanisms in chronic pain
CR Donnelly, AS Andriessen, G Chen, K Wang… - …, 2020 - Elsevier
Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …
Microglia: sculptors of neuropathic pain?
H Ward, SJ West - Royal Society open science, 2020 - royalsocietypublishing.org
Neuropathic pain presents a huge societal and individual burden. The limited efficacy of
current analgesics, diagnostic markers and clinical trial outcome measures arises from an …
current analgesics, diagnostic markers and clinical trial outcome measures arises from an …
Cellular and molecular mechanisms driving neuropathic pain: recent advancements and challenges
Introduction: Current pharmacotherapeutics for neuropathic pain offer only symptomatic
relief without treating the underlying pathophysiology. Additionally, they are associated with …
relief without treating the underlying pathophysiology. Additionally, they are associated with …