Chronic pain relief remains an unmet medical need. Current research points to a substantial
contribution of glia-neuron interaction in its pathogenesis. Particularly, microglia play a …

Pain is a defense system that responds rapidly to harmful internal and external stimuli
through the somatosensory neuronal pathway. However, damage to the nervous system …

The microglia, once thought only to be supporting cells of the central nervous system (CNS),
are now recognized to play essential roles in many pathologies. Many studies within the last …

Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Microglia play an important role in the central sensitization and chronic pain. However, a
direct connection between microglial function and pain development in vivo remains …

This special issue of Experimental Neurology is devoted to the role of Microglia and Chronic
Pain. Chronic pain affects 116 million people per year in the United States, which is more …

Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …

Neuropathic pain presents a huge societal and individual burden. The limited efficacy of
current analgesics, diagnostic markers and clinical trial outcome measures arises from an …

Introduction: Current pharmacotherapeutics for neuropathic pain offer only symptomatic
relief without treating the underlying pathophysiology. Additionally, they are associated with …