N-acetylcysteine pharmacology and applications in rare diseases—Repurposing an old antioxidant

SA Sahasrabudhe, MR Terluk, RV Kartha - Antioxidants, 2023 - mdpi.com
N-acetylcysteine (NAC), a precursor of cysteine and, thereby, glutathione (GSH), acts as an
antioxidant through a variety of mechanisms, including oxidant scavenging, GSH …

[HTML][HTML] N-acetylcysteine: A potential treatment for substance use disorders

RL Tomko, JL Jones, AK Gilmore, KT Brady… - Current …, 2018 - ncbi.nlm.nih.gov
Pharmacologic treatment options for many substance use disorders (SUDs) are limited. This
is especially true for cocaine use disorder and cannabis use disorder, for which there are no …

N-Acetylcysteine (NAC): Impacts on Human Health

MCS Tenório, NG Graciliano, FA Moura, ACM Oliveira… - Antioxidants, 2021 - mdpi.com
N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …

Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits

GF Rushworth, IL Megson - Pharmacology & therapeutics, 2014 - Elsevier
Abstract N-acetyl-l-cysteine (NAC) has long been used therapeutically for the treatment of
acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) …

Mechanisms and therapeutics of n-acetylcysteine: a recent update

R Shetty, N Udupa, S Mutalik… - Research Journal of …, 2019 - indianjournals.com
N-acetylcysteine (NAC), a precursor and a source of glutathione, which has been used for
past four decades, with well-established safety, widely used for the treatment of …

[图书][B] The therapeutic use of N-acetylcysteine (NAC) in medicine

RE Frye, M Berk - 2019 - Springer
I work in the field of autism where effective treatments are few and treatment targets are still
ill defined. One principle when looking for a potential effective treatment, especially for …

[HTML][HTML] The multifaceted therapeutic role of N-acetylcysteine (NAC) in disorders characterized by oxidative stress

G Raghu, M Berk, PA Campochiaro… - Current …, 2021 - ncbi.nlm.nih.gov
Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …

Biological activities and potential oral applications of N‐acetylcysteine: progress and prospects

Y Pei, H Liu, Y Yang, Y Yang, Y Jiao… - Oxidative medicine …, 2018 - Wiley Online Library
N‐Acetylcysteine (NAC), a cysteine prodrug and glutathione (GSH) precursor, has been
used for several decades in clinical therapeutic practices as a mucolytic agent and for the …

Pharmacokinetics and Safety of Single and Multiple Doses of Oral N-Acetylcysteine in Healthy Chinese and Caucasian Volunteers: An Open-Label, Phase I Clinical …

A Papi, AFD Di Stefano, M Radicioni - Advances in Therapy, 2021 - Springer
Introduction Few studies have evaluated whether the pharmacokinetics of N-acetyl-cysteine
(NAC) are different in Chinese and Caucasian individuals. Methods This single-and multiple …

Intravenous administration of stable-labeled N-acetylcysteine demonstrates an indirect mechanism for boosting glutathione and improving redox status

J Zhou, LD Coles, RV Kartha, N Nash, U Mishra… - Journal of …, 2015 - Elsevier
There is an increasing interest in using N-acetylcysteine (NAC) as a treatment for
neurodegenerative disorders to increase glutathione (GSH) levels and its redox status. The …