N-acetylcysteine pharmacology and applications in rare diseases—Repurposing an old antioxidant
SA Sahasrabudhe, MR Terluk, RV Kartha - Antioxidants, 2023 - mdpi.com
N-acetylcysteine (NAC), a precursor of cysteine and, thereby, glutathione (GSH), acts as an
antioxidant through a variety of mechanisms, including oxidant scavenging, GSH …
antioxidant through a variety of mechanisms, including oxidant scavenging, GSH …
[HTML][HTML] N-acetylcysteine: A potential treatment for substance use disorders
Pharmacologic treatment options for many substance use disorders (SUDs) are limited. This
is especially true for cocaine use disorder and cannabis use disorder, for which there are no …
is especially true for cocaine use disorder and cannabis use disorder, for which there are no …
N-Acetylcysteine (NAC): Impacts on Human Health
MCS Tenório, NG Graciliano, FA Moura, ACM Oliveira… - Antioxidants, 2021 - mdpi.com
N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …
Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits
GF Rushworth, IL Megson - Pharmacology & therapeutics, 2014 - Elsevier
Abstract N-acetyl-l-cysteine (NAC) has long been used therapeutically for the treatment of
acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) …
acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) …
Mechanisms and therapeutics of n-acetylcysteine: a recent update
N-acetylcysteine (NAC), a precursor and a source of glutathione, which has been used for
past four decades, with well-established safety, widely used for the treatment of …
past four decades, with well-established safety, widely used for the treatment of …
[图书][B] The therapeutic use of N-acetylcysteine (NAC) in medicine
I work in the field of autism where effective treatments are few and treatment targets are still
ill defined. One principle when looking for a potential effective treatment, especially for …
ill defined. One principle when looking for a potential effective treatment, especially for …
[HTML][HTML] The multifaceted therapeutic role of N-acetylcysteine (NAC) in disorders characterized by oxidative stress
G Raghu, M Berk, PA Campochiaro… - Current …, 2021 - ncbi.nlm.nih.gov
Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …
Biological activities and potential oral applications of N‐acetylcysteine: progress and prospects
Y Pei, H Liu, Y Yang, Y Yang, Y Jiao… - Oxidative medicine …, 2018 - Wiley Online Library
N‐Acetylcysteine (NAC), a cysteine prodrug and glutathione (GSH) precursor, has been
used for several decades in clinical therapeutic practices as a mucolytic agent and for the …
used for several decades in clinical therapeutic practices as a mucolytic agent and for the …
Pharmacokinetics and Safety of Single and Multiple Doses of Oral N-Acetylcysteine in Healthy Chinese and Caucasian Volunteers: An Open-Label, Phase I Clinical …
A Papi, AFD Di Stefano, M Radicioni - Advances in Therapy, 2021 - Springer
Introduction Few studies have evaluated whether the pharmacokinetics of N-acetyl-cysteine
(NAC) are different in Chinese and Caucasian individuals. Methods This single-and multiple …
(NAC) are different in Chinese and Caucasian individuals. Methods This single-and multiple …
Intravenous administration of stable-labeled N-acetylcysteine demonstrates an indirect mechanism for boosting glutathione and improving redox status
J Zhou, LD Coles, RV Kartha, N Nash, U Mishra… - Journal of …, 2015 - Elsevier
There is an increasing interest in using N-acetylcysteine (NAC) as a treatment for
neurodegenerative disorders to increase glutathione (GSH) levels and its redox status. The …
neurodegenerative disorders to increase glutathione (GSH) levels and its redox status. The …