Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen

CL Gorrie, M Mirčeta, RR Wick, LM Judd… - Nature …, 2022 - nature.com
Klebsiella pneumoniae is a major cause of opportunistic healthcare-associated infections,
which are increasingly complicated by the presence of extended-spectrum beta-lactamases …

Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia

KL Wyres, TNT Nguyen, MMC Lam, LM Judd… - Genome medicine, 2020 - Springer
Background Klebsiella pneumoniae is a leading cause of bloodstream infection (BSI).
Strains producing extended-spectrum beta-lactamases (ESBLs) or carbapenemases are …

Whole-genome sequencing of human clinical Klebsiella pneumoniae isolates reveals misidentification and misunderstandings of Klebsiella pneumoniae, Klebsiella …

SW Long, SE Linson, M Ojeda Saavedra, C Cantu… - Msphere, 2017 - Am Soc Microbiol
Klebsiella pneumoniae is a major threat to public health, causing significant morbidity and
mortality worldwide. The emergence of highly drug-resistant strains is particularly …

Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

TJ Kochan, SH Nozick, RL Medernach… - BMC infectious …, 2022 - Springer
Background Klebsiella pneumoniae strains have been divided into two major categories:
classical K. pneumoniae, which are frequently multidrug-resistant and cause hospital …

A high‐resolution genomic analysis of multidrug‐resistant hospital outbreaks of Klebsiella pneumoniae

H Chung The, A Karkey, D Pham Thanh… - EMBO molecular …, 2015 - embopress.org
Multidrug‐resistant (MDR) Klebsiella pneumoniae has become a leading cause of
nosocomial infections worldwide. Despite its prominence, little is known about the genetic …

Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing

ES Snitkin, AM Zelazny, PJ Thomas, F Stock… - Science translational …, 2012 - science.org
The Gram-negative bacteria Klebsiella pneumoniae is a major cause of nosocomial
infections, primarily among immunocompromised patients. The emergence of strains …

Large-scale genomic analysis of global Klebsiella pneumoniae plasmids reveals multiple simultaneous clusters of carbapenem-resistant hypervirulent strains

A Spadar, J Perdigão, S Campino, TG Clark - Genome medicine, 2023 - Springer
Abstract Background Klebsiella pneumoniae (Kp) Gram-negative bacteria cause
nosocomial infections and rapidly acquire antimicrobial resistance (AMR), which makes it a …

Evolution and Epidemiology of Multidrug-Resistant Klebsiella pneumoniae in the United Kingdom and Ireland

D Moradigaravand, V Martin, SJ Peacock, J Parkhill - MBio, 2017 - Am Soc Microbiol
Klebsiella pneumoniae is a human commensal and opportunistic pathogen that has become
a leading causative agent of hospital-based infections over the past few decades. The …

Molecular epidemiology of colonizing and infecting isolates of Klebsiella pneumoniae

RM Martin, J Cao, S Brisse, V Passet, W Wu, L Zhao… - MSphere, 2016 - Am Soc Microbiol
Klebsiella pneumoniae is among the most common causes of hospital-acquired infections
and has emerged as an urgent threat to public health due to carbapenem antimicrobial …