Lactobacillus crispatus inhibits growth of Gardnerella vaginalis and Neisseria gonorrhoeae on a porcine vaginal mucosa model

LM Breshears, VL Edwards, J Ravel, ML Peterson - BMC microbiology, 2015 - Springer
Background The vaginal microbiota can impact the susceptibility of women to bacterial
vaginosis (BV) and sexually transmitted infections (STIs). BV is characterized by depletion of …

Gardnerella vaginalis alters cervicovaginal epithelial cell function through microbe-specific immune responses

L Anton, B Ferguson, ES Friedman, KD Gerson… - Microbiome, 2022 - Springer
Background The cervicovaginal (CV) microbiome is highly associated with vaginal health
and disease in both pregnant and nonpregnant individuals. An overabundance of …

[PDF][PDF] Vaginal microbiota and viral sexually transmitted diseases

C Nardis, L Mosca, P Mastromarino - Ann Ig, 2013 - seu-roma.it
Healthy vaginal microbiota is an important biological barrier to pathogenic microorganisms.
When this predominantly Lactobacillus community is disrupted, decreased in abundance …

Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective

RM Brotman - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Vaginal bacterial communities are thought to help prevent sexually transmitted infections.
Bacterial vaginosis (BV) is a common clinical syndrome in which the protective lactic acid …

Connecting the dots: Translating the vaginal microbiome into a drug

LA Lagenaur, A Hemmerling, C Chiu… - The Journal of …, 2021 - academic.oup.com
A Lactobacillus-dominated vaginal microbiota (VMB) has been associated with health and
considered an important host defense mechanism against urogenital infections. Conversely …

Comparative genomics of human Lactobacillus crispatus isolates reveals genes for glycosylation and glycogen degradation: implications for in vivo dominance of the …

C Van Der Veer, RY Hertzberger, SM Bruisten… - Microbiome, 2019 - Springer
Background A vaginal microbiota dominated by lactobacilli (particularly Lactobacillus
crispatus) is associated with vaginal health, whereas a vaginal microbiota not dominated by …

Bacteria in the vaginal microbiome alter the innate immune response and barrier properties of the human vaginal epithelia in a species-specific manner

SY Doerflinger, AL Throop… - The Journal of …, 2014 - academic.oup.com
Background. Bacterial vaginosis increases the susceptibility to sexually transmitted
infections and negatively affects women's reproductive health. Methods. To investigate host …

Association of high-risk sexual behaviour with diversity of the vaginal microbiota and abundance of Lactobacillus

JM Wessels, J Lajoie, D Vitali, K Omollo, J Kimani… - PLoS …, 2017 - journals.plos.org
Objective To compare the vaginal microbiota of women engaged in high-risk sexual
behaviour (sex work) with women who are not engaged in high-risk sexual behaviour …

Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health

WJY Chee, SY Chew, LTL Than - Microbial cell factories, 2020 - Springer
Human vagina is colonised by a diverse array of microorganisms that make up the normal
microbiota and mycobiota. Lactobacillus is the most frequently isolated microorganism from …

Host and microbiome interplay shapes the vaginal microenvironment

MS Kwon, HK Lee - Frontiers in immunology, 2022 - frontiersin.org
The female reproductive tract harbors a unique microbiome, especially the vagina. The
human vaginal microbiome exhibits a low diversity and is dominated by Lactobacillus …