Aging has a remarkable effect on cardiovascular homeostasis and it is known as the major
non-modifiable risk factor in the development of hypertension. Medications targeting …

The angiotensin (Ang) type 1 receptor (AT1R) promotes functional and structural integrity of
the arterial wall to contribute to vascular homeostasis, but this receptor also promotes …

Purinergic signaling, mediated mainly by G protein-coupled P2Y receptors (P2YRs), is now
attracting attention as a new therapeutic target for preventing or treating cardiovascular …

Highlights•Distribution and function of P2Y 6 R.•P2Y 6 R participated in pathogenesis of
atherosclerosis and other cardiovascular diseases.•The development of P2Y 6 R …

Hypertension is the leading cause of morbidity and mortality globally among all
cardiovascular diseases. Purinergic signalling plays a crucial role in hypertension through …

Platelets play a key role in primary haemostasis and also represent an important interface
between thrombosis, immunity, and atherogenesis. 1 Platelet-triggered inflammatory …

Purinergic P2 receptors are critical regulators of several functions within the vascular
system, including platelet aggregation, vascular inflammation, and vascular tone. However …

ATP and UTP are endogenous agonists of P2Y2/4 receptors. To define the in vivo effects of
P2Y2 receptor activation on blood pressure and urinary excretion, we compared the …

Background P2Y6, a purinergic receptor for UDP, is enriched in atherosclerotic lesions and
is implicated in pro-inflammatory responses of key vascular cell types and macrophages …

Cardiovascular disease is a major cause of morbidity and mortality worldwide. Innovative
new treatment options for this cardiovascular pandemic are urgently needed. Activation of …