Endothelial β3-Adrenoreceptors Mediate Nitric Oxide–Dependent Vasorelaxation of Coronary Microvessels in Response to the Third-Generation β-Blocker Nebivolol

C Dessy, J Saliez, P Ghisdal, G Daneau, II Lobysheva… - Circulation, 2005 - Am Heart Assoc
Background—The therapeutic effects of nonspecific β-blockers are limited by
vasoconstriction, thus justifying the interest in molecules with ancillary vasodilating …

Nebivolol: A Third-Generation β-Blocker That Augments Vascular Nitric Oxide Release: Endothelial β2-Adrenergic Receptor–Mediated Nitric Oxide Production

MAW Broeders, PA Doevendans, BCAM Bekkers… - Circulation, 2000 - Am Heart Assoc
Background—Nebivolol is a β1-selective adrenergic receptor antagonist with proposed nitric
oxide (NO)–mediated vasodilating properties in humans. In this study, we explored whether …

Endothelial β3-Adrenoceptors Mediate Vasorelaxation of Human Coronary Microarteries Through Nitric Oxide and Endothelium-Dependent Hyperpolarization

C Dessy, S Moniotte, P Ghisdal, X Havaux… - Circulation, 2004 - Am Heart Assoc
Background—Coronary vessel tone is modulated in part by β-adrenergic relaxation.
However, the implication of specific β-adrenoceptor subtypes and their downstream …

Involvement of the β3 adrenoceptor in nebivolol-induced vasorelaxation in the rat aorta

AA de Groot, MJ Mathy, PA van Zwieten… - Journal of …, 2003 - journals.lww.com
Nebivolol is a highly selective β 1 adrenoceptor blocker with additional vasodilating
properties. Although it has been shown that the nebivolol-induced vasorelaxation is nitric …

Nebivolol: A Highly Selective β1‐Adrenergic Receptor Blocker That Causes Vasodilation by Increasing Nitric Oxide

S Gupta, HM Wright - Cardiovascular therapeutics, 2008 - Wiley Online Library
Nebivolol (Bystolic®) is a cardioselective beta 1 (β1)‐adrenergic receptor blocker with
endothelium‐dependent vasodilating properties. The endothelium‐dependent relaxation …

Nebivolol: a selective β1-adrenergic receptor antagonist that relaxes vascular smooth muscle by nitric oxide-and cyclic GMP-dependent mechanisms

LJ Ignarro, RE Byrns, K Trinh, M Sisodia, GM Buga - Nitric Oxide, 2002 - Elsevier
Nebivolol is a highly selective β1-adrenergic receptor antagonist that also possesses
vasodilator properties that are attributed largely to nitric oxide (NO). The objective of the …

Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation

A Maffei, A Di Pardo, R Carangi, P Carullo, R Poulet… - …, 2007 - Am Heart Assoc
Nebivolol is a β1-adrenergic receptor antagonist that also reduces blood pressure by
evoking endothelial NO production and vasodilation. We aimed at assessing whether …

Mixed β3‐adrenoceptor agonist and α1‐adrenoceptor antagonist properties of nebivolol in rat thoracic aorta

B Rozec, TT Quang, J Noireaud… - British journal of …, 2006 - Wiley Online Library
Nebivolol, a selective β‐adrenoceptor (β1‐AR) antagonist, induces vasodilatation by an
endothelium‐and NO‐cGMP‐dependent pathway. However, the mechanisms involved in …

Inositol phosphate metabolism and nitric-oxide synthase activity in endothelial cells are involved in the vasorelaxant activity of nebivolol

A Parenti, S Filippi, S Amerini, HJ Granger… - … of Pharmacology and …, 2000 - ASPET
Nebivolol is a recently developed β-blocker provided with vasodilator properties. Because
the mechanism of the putative endothelium-dependent effect of this β-adrenoceptor blocker …

Experimental evidences of nitric oxide‐dependent vasodilatory activity of nebivolol, a third‐generation β‐blocker

L Ignarro - Blood Pressure, 2004 - Taylor & Francis
Nebivolol is a new and selective β 1‐adrenergic receptor antagonist whose haemodynamic
profile is different from that of classical β‐blockers. The blood pressure lowering effects of …