Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
Induced pluripotent stem cells as a disease modeling and drug screening platform
Induced pluripotent stem cells (iPSCs) hold great hopes for therapeutic application in
various diseases. Although ongoing research is dedicated to achieving clinical translation of …
various diseases. Although ongoing research is dedicated to achieving clinical translation of …
Human-induced pluripotent stem cells in cardiovascular research: current approaches in cardiac differentiation, maturation strategies, and scalable production
Manifestations of cardiovascular diseases (CVDs) in a patient or a population differ based
on inherent biological makeup, lifestyle, and exposure to environmental risk factors. These …
on inherent biological makeup, lifestyle, and exposure to environmental risk factors. These …
Induced pluripotent stem cells for cardiovascular disease modeling and precision medicine: a scientific statement from the American Heart Association
K Musunuru, F Sheikh, RM Gupta… - Circulation: Genomic …, 2018 - Am Heart Assoc
Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …
physiology and disease at the cellular level. They also have the potential to be leveraged in …
Induced pluripotent stem cells in cardiovascular drug discovery
The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state
yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells …
yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells …
Human induced pluripotent stem cell–derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes
Disease models are essential for understanding cardiovascular disease pathogenesis and
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …
Human induced pluripotent stem cells as a platform for personalized and precision cardiovascular medicine
Human induced pluripotent stem cells (hiPSCs) have revolutionized the field of human
disease modeling, with an enormous potential to serve as paradigm shifting platforms for …
disease modeling, with an enormous potential to serve as paradigm shifting platforms for …
Human iPSC modeling of heart disease for drug development
Human induced pluripotent stem cells (hiPSCs) have emerged as a promising platform for
pharmacogenomics and drug development. In cardiology, they make it possible to produce …
pharmacogenomics and drug development. In cardiology, they make it possible to produce …
Utility of iPSC-derived cells for disease modeling, drug development, and cell therapy
MW Nicholson, CY Ting, DZH Chan, YC Cheng… - Cells, 2022 - mdpi.com
The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …
Human stem cells for modeling heart disease and for drug discovery
E Matsa, PW Burridge, JC Wu - Science translational medicine, 2014 - science.org
A major research focus in the field of cardiovascular medicine is the prospect of using stem
cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent …
cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent …
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