For high‐throughput anti‐cancer drug screening, microwell arrays may serve as an effective
tool to generate uniform and scalable tumor spheroids. However, microwell arrays are …

Hepatocellular carcinoma (HCC) poses a significant threat to human health and medical
care. Its dynamic microenvironment and stages of development will influence the treatment …

Three-dimensional (3D) culture via micropattern arrays to generate cellular spheroids
seems a promising in vitro biomimetic system for liver tissue engineering applications, such …

Generating microliver tissues to recapitulate hepatic function is of increasing importance in
tissue engineering and drug screening. But the limited availability of primary hepatocytes …

We fabricated a spheroid-forming unit (SFU) for efficient and economic production of cell
spheroids. We optimized the protocol for generating large and homogenous liver cancer cell …

Drug resistance is one of the major obstacles in the drug therapy of cancers. Efforts in this
area in pre-clinical research have focused on developing novel platforms to evaluate and …

Sacrificial gelatin microspheres can be developed as a cell delivery vehicle for non-
anchorage dependent cells–its incorporation into a macroscopic scaffold system not only …

In the drug therapy of tumor, efficient and stable drug screening platforms are required since
the drug efficacy varies individually. Here, inspired by the microstructures of hepatic lobules …

Spheroid-based three-dimensional (3D) liver culture models, offering a desirable biomimetic
microenvironment, are useful for recapitulating liver functions in vitro. However, a user …

The establishment of a reliable in vitro liver model for drug screening remains challenging
with respect to tethering the growth of hepatocyte spheroids and adapting to the current high …