The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation

L Yu, N Maishi, E Akahori, A Hasebe, R Takeda… - Cancer …, 2022 - Wiley Online Library
Recent studies have demonstrated a relationship between oral bacteria and systemic
inflammation. Endothelial cells (ECs), which line blood vessels, control the opening and …

Oral bacterium Streptococcus mutans promotes tumor metastasis through thrombosis formation

L Yu, Y Hong, N Maishi, AY Matsuda, Y Hida… - Cancer …, 2024 - Wiley Online Library
Thrombosis is a well‐known cardiovascular disease (CVD) complication that has caused
death in many patients with cancer. Oral bacteria have been reported to contribute to …

[HTML][HTML] Streptococcus mutans promotes tumor progression in oral squamous cell carcinoma

MS Tsai, YY Chen, WC Chen, MF Chen - Journal of Cancer, 2022 - ncbi.nlm.nih.gov
Oral squamous cell carcinoma (OSCC) is an aggressive head and neck cancer. Evidence
showed that some pathogenic bacteria are associated with periodontitis and oral cancer …

Cytotoxic T cell responses to Streptococcus are associated with improved prognosis of oral squamous cell carcinoma

J Wang, F Sun, X Lin, Z Li, X Mao, C Jiang - Experimental cell research, 2018 - Elsevier
Several species of Streptococcus, such as S. salivarius, S. mitis, and S. anginosus, are
found to extensively colonize the oral cavity and the upper respiratory tract, and have been …

Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175

J Abranches, L Zeng, M Bélanger… - Oral microbiology …, 2009 - Wiley Online Library
Introduction: Dissemination of oral bacteria into the bloodstream has been associated with
eating, oral hygiene, and dental procedures; including tooth extraction, endodontic …

Presence of Streptococcus infection in extra-oropharyngeal head and neck squamous cell carcinoma and its implication in carcinogenesis

K Shiga, M Tateda, S Saijo, T Hori… - Oncology …, 2001 - spandidos-publications.com
To investigate the involvement of S. anginosus infection in head and neck cancer in the
extra-oropharyngeal cavity, we analyzed 3 DNA samples prepared from squamous cell …

Invasive Streptococcus mutans induces inflammatory cytokine production in human aortic endothelial cells via regulation of intracellular toll‐like receptor 2 and …

E Nagata, T Oho - Molecular Oral Microbiology, 2017 - Wiley Online Library
Streptococcus mutans, the primary etiologic agent of dental caries, can gain access to the
bloodstream and has been associated with cardiovascular disease. However, the roles of S …

Potential involvement of Streptococcus mutans possessing collagen binding protein Cnm in infective endocarditis

R Nomura, M Otsugu, M Hamada, S Matayoshi… - Scientific reports, 2020 - nature.com
Streptococcus mutans, a significant contributor to dental caries, is occasionally isolated from
the blood of patients with infective endocarditis. We previously showed that S. mutans …

Porphyromonas gingivalis increases the invasiveness of oral cancer cells by upregulating IL-8 and MMPs

NH Ha, DG Park, BH Woo, JI Choi, BS Park, YD Kim… - Cytokine, 2016 - Elsevier
Recent studies indicate that chronic inflammation promotes the aggressiveness of cancers.
However, the direct molecular mechanisms underlying a functional link between chronic …

Different frequencies of Streptococcus anginosus infection in oral cancer and esophageal cancer

E Morita, M Narikiyo, A Yano, E Nishimura… - Cancer …, 2003 - Wiley Online Library
Multiple cancers frequently occur in the upper aerodigestive tract. The high incidence rate of
multiple carcinomas in this region is often explained in terms of involvement of the same …