Results The tumor group was significantly more methylated in both genes than the cirrhosis
and the control groups. The RASSF1A gene was highly methylated in advanced tumor …

This study was aimed to evaluate the clinical value of plasma methylation analysis of a
panel of four genes (APC, GSTP1, RASSF1A, and SFRP1), which was identified by our …

Background: Hypermethylation of the RASSF1A [Ras association (RalGDS/AF-6) domain
family member 1A] gene is frequently observed in hepatocellular carcinoma (HCC). We …

Background Hypermethylation of the promoter region of the RAS association domain family
1A gene (RASSF1A) occurs widely in hepatocellular carcinoma (HCC) tissues. While the …

Purpose: Most hepatocellular carcinomas (HCC) are diagnosed at an advanced stage.
Hypermethylation of CpG islands in promoter regions is now recognized as an important …

BACKGROUND AND STUDY AIMS: The detection of the promoter hypermethylation of
RASSF1A in serum DNA could be a valuable biomarker for early detection of preneoplastic …

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common human
malignancies and its impact on mortality is significant and well documented …

Aim Aberrant methylation of the promoter, P2, and the first exon, E1, regions of the tumor
suppressor gene RASSF1A, have been associated with hepatocellular carcinoma (HCC) …

BACKGROUND: DNA methylation status is one of the most prevalent molecular alterations
in human cancers. Identification of powerful diagnostic and prognostic biomarkers for …

Background RAS association domain family protein 1A (RASSF1A) promoter
hypermethylation is suggested to be linked to hepatocellular carcinoma (HCC), but the …