G protein polymorphisms in hypertension, atherosclerosis, and diabetes

W Siffert - Annu. Rev. Med., 2005 - annualreviews.org
A common C825T polymorphism in the gene GNB3, which encodes the β3 subunit of
heterotrimeric G proteins, was identified in cell lines from patients with hypertension. The …

Molecular genetics of G proteins and atherosclerosis risk

W Siffert - Basic Research in Cardiology, 2001 - Springer
Using a classical candidate gene approach, we have described a common C825T
polymorphism in the gene GNB3 which encodes the ubiquitously expressed β3 subunit of …

G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk: An Updated Review

A Semplicini, T Grandi, C Sandonà, A Cattelan… - High Blood Pressure & …, 2015 - Springer
Hypertension is a common disorder of multifactorial origin that constitutes a major risk factor
for cardiovascular events such as stroke and myocardial infarction. The subunits of the …

The 825C/T polymorphism of the G-protein subunit β3 is not related to hypertension

E Brand, SM Herrmann, V Nicaud, JB Ruidavets… - …, 1999 - Am Heart Assoc
A polymorphism at position 825 (C→ T) of the cDNA that encodes the β3 subunit (GNB3) of
the pertussis toxin–sensitive G protein was recently shown to be associated with human …

G-protein β3 subunit 825T allele and hypertension

W Siffert - Current hypertension reports, 2003 - Springer
The G-protein β3 subunit (GNB3) C825T polymorphism was detected through a classical
candidate gene approach using cell lines with enhanced G-protein activation from patients …

Lack of association between the G protein β3 subunit gene and essential hypertension in Chinese: a case-control and a family-based study

X Huang, Z Ju, Y Song, H Zhang, K Sun, H Lu… - Journal of molecular …, 2003 - Springer
Abstract A C825T polymorphism of the gene encoding the G protein β 3 subunit (GNB3) is
associated with enhanced G protein activity and increased intracellular signal transduction …

Association between a polymorphism in the G protein β3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction

C Hengstenberg, H Schunkert, B Mayer… - Cardiovascular …, 2001 - academic.oup.com
Objective: A polymorphism at position 825 (C→ T) of the G protein β3 (GNB3) gene was
found to be associated with enhanced transmembrane signalling as well as with an …

G-protein β3 subunit C825T polymorphism: no association with risk for hypertension and obesity

A Snapir, P Heinonen, TP Tuomainen… - Journal of …, 2001 - journals.lww.com
Objective Several recent studies have indicated that a C825T polymorphism in the gene
encoding the G-protein β 3 subunit is a significant risk factor for hypertension and obesity. In …

G protein β3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes

JM Fernández-Real, G Peñarroja, C Richart… - …, 2003 - Am Heart Assoc
A common polymorphism (825 C/T) in exon 10 of the GNB3 gene, that encodes for the β-3
subunit, has been associated with different degrees of activation of heterotrimeric guanine …

G protein β3 gene: structure, promoter, and additional polymorphisms

D Rosskopf, S Busch, I Manthey, W Siffert - Hypertension, 2000 - Am Heart Assoc
Recent studies have shown that a polymorphism (C825T) in the gene encoding the G
protein β3 subunit (GNB3) is associated with hypertension and obesity. We characterized …