G protein polymorphisms in hypertension, atherosclerosis, and diabetes
W Siffert - Annu. Rev. Med., 2005 - annualreviews.org
A common C825T polymorphism in the gene GNB3, which encodes the β3 subunit of
heterotrimeric G proteins, was identified in cell lines from patients with hypertension. The …
heterotrimeric G proteins, was identified in cell lines from patients with hypertension. The …
Molecular genetics of G proteins and atherosclerosis risk
W Siffert - Basic Research in Cardiology, 2001 - Springer
Using a classical candidate gene approach, we have described a common C825T
polymorphism in the gene GNB3 which encodes the ubiquitously expressed β3 subunit of …
polymorphism in the gene GNB3 which encodes the ubiquitously expressed β3 subunit of …
G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk: An Updated Review
A Semplicini, T Grandi, C Sandonà, A Cattelan… - High Blood Pressure & …, 2015 - Springer
Hypertension is a common disorder of multifactorial origin that constitutes a major risk factor
for cardiovascular events such as stroke and myocardial infarction. The subunits of the …
for cardiovascular events such as stroke and myocardial infarction. The subunits of the …
The 825C/T polymorphism of the G-protein subunit β3 is not related to hypertension
E Brand, SM Herrmann, V Nicaud, JB Ruidavets… - …, 1999 - Am Heart Assoc
A polymorphism at position 825 (C→ T) of the cDNA that encodes the β3 subunit (GNB3) of
the pertussis toxin–sensitive G protein was recently shown to be associated with human …
the pertussis toxin–sensitive G protein was recently shown to be associated with human …
G-protein β3 subunit 825T allele and hypertension
W Siffert - Current hypertension reports, 2003 - Springer
The G-protein β3 subunit (GNB3) C825T polymorphism was detected through a classical
candidate gene approach using cell lines with enhanced G-protein activation from patients …
candidate gene approach using cell lines with enhanced G-protein activation from patients …
Lack of association between the G protein β3 subunit gene and essential hypertension in Chinese: a case-control and a family-based study
Abstract A C825T polymorphism of the gene encoding the G protein β 3 subunit (GNB3) is
associated with enhanced G protein activity and increased intracellular signal transduction …
associated with enhanced G protein activity and increased intracellular signal transduction …
Association between a polymorphism in the G protein β3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction
C Hengstenberg, H Schunkert, B Mayer… - Cardiovascular …, 2001 - academic.oup.com
Objective: A polymorphism at position 825 (C→ T) of the G protein β3 (GNB3) gene was
found to be associated with enhanced transmembrane signalling as well as with an …
found to be associated with enhanced transmembrane signalling as well as with an …
G-protein β3 subunit C825T polymorphism: no association with risk for hypertension and obesity
A Snapir, P Heinonen, TP Tuomainen… - Journal of …, 2001 - journals.lww.com
Objective Several recent studies have indicated that a C825T polymorphism in the gene
encoding the G-protein β 3 subunit is a significant risk factor for hypertension and obesity. In …
encoding the G-protein β 3 subunit is a significant risk factor for hypertension and obesity. In …
G protein β3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes
JM Fernández-Real, G Peñarroja, C Richart… - …, 2003 - Am Heart Assoc
A common polymorphism (825 C/T) in exon 10 of the GNB3 gene, that encodes for the β-3
subunit, has been associated with different degrees of activation of heterotrimeric guanine …
subunit, has been associated with different degrees of activation of heterotrimeric guanine …
G protein β3 gene: structure, promoter, and additional polymorphisms
D Rosskopf, S Busch, I Manthey, W Siffert - Hypertension, 2000 - Am Heart Assoc
Recent studies have shown that a polymorphism (C825T) in the gene encoding the G
protein β3 subunit (GNB3) is associated with hypertension and obesity. We characterized …
protein β3 subunit (GNB3) is associated with hypertension and obesity. We characterized …