c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells

ER Hahm, KB Singh, SV Singh - Cell Cycle, 2016 - Taylor & Francis
Honokiol (HNK), a highly promising phytochemical derived from Magnolia officinalis plant,
exhibits in vitro and in vivo anticancer activity against prostate cancer but the underlying …

Honokiol inhibits androgen receptor activity in prostate cancer cells

ER Hahm, AI Karlsson, MY Bonner, JL Arbiser… - The …, 2014 - Wiley Online Library
BACKGROUND We have shown previously that honokiol (HNK), a bioactive component of
the medicinal plant Magnolia officinalis, inhibits growth of human prostate cancer cells in …

Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells

K Shigemura, JL Arbiser, SY Sun… - … Journal of the …, 2007 - Wiley Online Library
BACKGROUND. Honokiol, a soluble nontoxic natural product derived from Magnolia spp.,
has been shown to induce apoptosis in malignant cells. The effect of honokiol and the …

Honokiol, a Constituent of Oriental Medicinal Herb Magnolia officinalis, Inhibits Growth of PC-3 Xenografts In vivo in Association with Apoptosis Induction

ER Hahm, JA Arlotti, SW Marynowski, SV Singh - Clinical cancer research, 2008 - AACR
Purpose: This study was undertaken to determine the efficacy of honokiol, a constituent of
oriental medicinal herb Magnolia officinalis, against human prostate cancer cells in culture …

Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and …

ER Hahm, SV Singh - Molecular cancer therapeutics, 2007 - AACR
The present study was undertaken to gain insights into the mechanism of cell cycle arrest
caused by honokiol, a constituent of oriental herb Magnolia officinalis. The honokiol …

Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast …

EJ Park, HY Min, HJ Chung, JY Hong, YJ Kang… - Cancer letters, 2009 - Elsevier
Honokiol is a naturally occurring neolignan abundant in Magnoliae Cortex and has showed
anti-proliferative and pro-apoptotic effects in a wide range of human cancer cells. However …

[HTML][HTML] Honokiol: a review of its anticancer potential and mechanisms

CP Ong, WL Lee, YQ Tang, WH Yap - Cancers, 2019 - mdpi.com
Cancer is characterised by uncontrolled cell division and abnormal cell growth, which is
largely caused by a variety of gene mutations. There are continuous efforts being made to …

[HTML][HTML] Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells

S Arora, A Bhardwaj, SK Srivastava, S Singh… - PloS one, 2011 - journals.plos.org
Survival rates for patients with pancreatic cancer are extremely poor due to its asymptomatic
progression to advanced and metastatic stage for which current therapies remain largely …

Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets

K Banik, AM Ranaware, V Deshpande… - Pharmacological …, 2019 - Elsevier
In spite of billions of dollars expended on cancer research every year, the incidence rate and
the mortality rate due to this widespread disease has increased drastically over the last few …

[HTML][HTML] Downregulation of STAT3 and activation of MAPK are involved in the induction of apoptosis by HNK in glioblastoma cell line U87

Y Zhang, X Ren, M Shi, Z Jiang… - Oncology …, 2014 - spandidos-publications.com
Abstract Honokiol [3, 5-di-(2-propenyl)-1, 1-biphenyl-2, 2-diol; HNK], a natural bioactive
molecular compound isolated from the Magnolia officinalis, exhibits potent antitumor activity …