Complete protection from repeated vaginal simian-human immunodeficiency virus exposures in macaques by a topical gel containing tenofovir alone or with …
UM Parikh, C Dobard, S Sharma, M Cong, H Jia… - Journal of …, 2009 - Am Soc Microbiol
New-generation gels that deliver potent antiretroviral drugs against human
immunodeficiency virus type 1 have renewed hopes for topical prophylaxis as a prevention …
immunodeficiency virus type 1 have renewed hopes for topical prophylaxis as a prevention …
Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue
C Dobard, S Sharma, A Martin, CP Pau… - Journal of …, 2012 - Am Soc Microbiol
ABSTRACT A vaginal gel containing 1% tenofovir (TFV) was found to be safe and effective
in reducing HIV infection in women when used pericoitally. Because of the long intracellular …
in reducing HIV infection in women when used pericoitally. Because of the long intracellular …
Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges
Topical preexposure prophylaxis interrupts HIV transmission at the site of mucosal
exposure. Intermittently dosed vaginal gels containing the HIV-1 reverse transcriptase …
exposure. Intermittently dosed vaginal gels containing the HIV-1 reverse transcriptase …
Pharmacokinetics of tenofovir following intravaginal and intrarectal administration of tenofovir gel to rhesus macaques
J Nuttall, A Kashuba, R Wang, N White… - Antimicrobial agents …, 2012 - Am Soc Microbiol
ABSTRACT Tenofovir gel (1%) is being developed as a microbicide for the prevention of
human immunodeficiency virus (HIV) infection and has been shown to reduce transmission …
human immunodeficiency virus (HIV) infection and has been shown to reduce transmission …
Tenofovir Disoproxil Fumarate Intravaginal Ring Protects High-Dose Depot Medroxyprogesterone Acetate–Treated Macaques From Multiple SHIV Exposures
JM Smith, P Srinivasan, RS Teller, Y Lo… - JAIDS Journal of …, 2015 - journals.lww.com
Preclinical HIV prevention models use either a single high-dose viral challenge in depot
medroxyprogesterone acetate–treated macaques or repeated viral challenges in cycling …
medroxyprogesterone acetate–treated macaques or repeated viral challenges in cycling …
Tenofovir disoproxil fumarate intravaginal ring for HIV pre-exposure prophylaxis in sexually active women: a phase 1, single-blind, randomised, controlled trial
Background An intravaginal ring that releases the tenofovir prodrug, tenofovir disoproxil
fumarate, provided 100% protection in macaques against simian HIV and was safe in a 14 …
fumarate, provided 100% protection in macaques against simian HIV and was safe in a 14 …
A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis
TJ Johnson, MR Clark, TH Albright… - Antimicrobial agents …, 2012 - Am Soc Microbiol
ABSTRACT A vaginal gel containing the antiretroviral tenofovir (TFV) recently demonstrated
39% protection against HIV infection in women. We designed and evaluated a novel …
39% protection against HIV infection in women. We designed and evaluated a novel …
Safety and pharmacokinetics of intravaginal rings delivering tenofovir in pig-tailed macaques
JA Moss, AM Malone, TJ Smith… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Antiretroviral-based microbicides applied topically to the vagina may play an important role
in protecting women from HIV infection. Incorporation of the nucleoside reverse transcriptase …
in protecting women from HIV infection. Incorporation of the nucleoside reverse transcriptase …
Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication
The HIV reverse-transcriptase inhibitor, tenofovir, was recently formulated into a vaginal gel
for use as a microbicide. In human trials, a 1% tenofovir gel inhibited HIV sexual …
for use as a microbicide. In human trials, a 1% tenofovir gel inhibited HIV sexual …
A phase 1 randomized placebo-controlled safety and pharmacokinetic trial of a tenofovir disoproxil fumarate vaginal ring
Background: Tenofovir disoproxil fumarate (TDF), a prodrug of tenofovir (TFV), may be ideal
for topical HIV preexposure prophylaxis because it has higher tissue and cell permeability …
for topical HIV preexposure prophylaxis because it has higher tissue and cell permeability …