Background & Aims: Intestinal fibrosis and stricture formation are serious complications of
Crohn's disease, often requiring surgical intervention. Unfortunately, the mechanisms …

Background The natural history of Crohn's disease follows a path of progression from an
inflammatory to a fibrostenosing disease, with most patients requiring surgical resection of …

Intestinal fibrosis is a serious complication of Crohn's disease (CD) that can lead to stricture
formation, which requires surgery. Mechanisms underlying intestinal fibrosis remain elusive …

Intestinal fibrosis is a major complication of Crohn disease (CD), but the precise mechanism
by which it occurs is incompletely understood. As a result, specific therapies to halt or even …

Intestinal fibrosis–a chronic and progressive process mediated by several factors–occurs in
several fibrostenosing enteropathies, but most frequently in patients with Crohn's disease …

The concepts on the pathophysiology of intestinal fibrosis in Crohn's disease (CD) have
changed in recent years. Some years ago fibrosis was regarded to be a consequence of …

Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of
environmental and genetic factors in susceptible individuals. It is characterized by chronic …

Background: Despite significant progress in the research of fibrosis in various organs,
fibrosis remains a poorly understood complication of Crohn's disease (CD). We analyzed …

Objective. Gastrointestinal involvement occurs in up to 90% of patients with SSc. Animal
models of SSc mimic some of the pathophysiological disease processes of SSc. The …

Background and aims: Intestinal fibrosis is a common complication of IBD that can become
seriously symptomatic and may require surgical intervention if stricture formation ensues …