Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis
GA Grassl, Y Valdez, KSB Bergstrom, BA Vallance… - Gastroenterology, 2008 - Elsevier
Background & Aims: Intestinal fibrosis and stricture formation are serious complications of
Crohn's disease, often requiring surgical intervention. Unfortunately, the mechanisms …
Crohn's disease, often requiring surgical intervention. Unfortunately, the mechanisms …
Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: impact of a “Top-Down” approach to intestinal fibrosis in mice
LA Johnson, A Luke, K Sauder… - Inflammatory bowel …, 2012 - academic.oup.com
Background The natural history of Crohn's disease follows a path of progression from an
inflammatory to a fibrostenosing disease, with most patients requiring surgical resection of …
inflammatory to a fibrostenosing disease, with most patients requiring surgical resection of …
[HTML][HTML] SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis
KW McLarren, AE Cole, SB Weisser… - The American journal of …, 2011 - Elsevier
Intestinal fibrosis is a serious complication of Crohn's disease (CD) that can lead to stricture
formation, which requires surgery. Mechanisms underlying intestinal fibrosis remain elusive …
formation, which requires surgery. Mechanisms underlying intestinal fibrosis remain elusive …
Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis
SN Flier, H Tanjore, EG Kokkotou, H Sugimoto… - Journal of Biological …, 2010 - ASBMB
Intestinal fibrosis is a major complication of Crohn disease (CD), but the precise mechanism
by which it occurs is incompletely understood. As a result, specific therapies to halt or even …
by which it occurs is incompletely understood. As a result, specific therapies to halt or even …
Losartan reduces trinitrobenzene sulphonic acid‐induced colorectal fibrosis in rats
D Wengrower, G Zanninelli, G Latella… - Canadian Journal of …, 2012 - Wiley Online Library
Intestinal fibrosis–a chronic and progressive process mediated by several factors–occurs in
several fibrostenosing enteropathies, but most frequently in patients with Crohn's disease …
several fibrostenosing enteropathies, but most frequently in patients with Crohn's disease …
Factors promoting development of fibrosis in Crohn's disease
G Rogler, M Hausmann - Frontiers in medicine, 2017 - frontiersin.org
The concepts on the pathophysiology of intestinal fibrosis in Crohn's disease (CD) have
changed in recent years. Some years ago fibrosis was regarded to be a consequence of …
changed in recent years. Some years ago fibrosis was regarded to be a consequence of …
The role of cytokines in the fibrotic responses in Crohn's disease
Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of
environmental and genetic factors in susceptible individuals. It is characterized by chronic …
environmental and genetic factors in susceptible individuals. It is characterized by chronic …
Pathology of fibrosis in Crohn's disease—contribution to understanding its pathogenesis
N Zidar, C Langner, M Jerala, E Boštjančič… - Frontiers in …, 2020 - frontiersin.org
Background: Despite significant progress in the research of fibrosis in various organs,
fibrosis remains a poorly understood complication of Crohn's disease (CD). We analyzed …
fibrosis remains a poorly understood complication of Crohn's disease (CD). We analyzed …
Gut fibrosis with altered colonic contractility in a mouse model of scleroderma
NM Thoua, EC Derrett-Smith, K Khan, A Dooley… - …, 2012 - academic.oup.com
Objective. Gastrointestinal involvement occurs in up to 90% of patients with SSc. Animal
models of SSc mimic some of the pathophysiological disease processes of SSc. The …
models of SSc mimic some of the pathophysiological disease processes of SSc. The …
Intestinal fibrosis in inflammatory bowel disease—Current knowledge and future perspectives
F Rieder, C Fiocchi - Journal of Crohn's and Colitis, 2008 - academic.oup.com
Background and aims: Intestinal fibrosis is a common complication of IBD that can become
seriously symptomatic and may require surgical intervention if stricture formation ensues …
seriously symptomatic and may require surgical intervention if stricture formation ensues …