Heightened concentrations of reactive metabolites, including reactive oxygen species
(ROS), can damage all macromolecules leading to the erosion of cellular fidelity. In this …

Imbalances in the formation and clearance of reactive oxygen species (ROS) can lead to
oxidative stress and subsequent changes that affect all aspects of physiology. To limit and …

Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …

Significance: Reactive oxygen species (ROS) are generated during mitochondrial oxidative
metabolism, and are tightly controlled through homeostatic mechanisms to maintain …

Our understanding of reactive oxygen species (ROS)—a group of highly reactive chemicals
containing oxygen—has changed in the last few years from ROS as just harmful substances …

Reactive oxygen species (ROS) are by‐products of normal cell activity. They are produced
in many cellular compartments and play a major role in signaling pathways. Overproduction …

The intracellular redox state in the cell depends on the balance between the level of reactive
oxygen species (ROS) and the activity of defensive systems including antioxidant enzymes …

Cancer comprises a group of heterogeneous diseases encompassing high rates of
morbidity and mortality. Heterogeneity, which is a hallmark of cancer, is one of the main …

Reactive oxygen species (ROS), which were originally characterized in terms of their
harmful effects on cells and invading microorganisms, are increasingly implicated in various …

Oxidation-reduction reactions played a significant role in the chemical evolution of life forms
on oxygenated earth. Cellular respiration is dependent on such redox reactions, and any …