Little is known about the regulation and function of the Notch1 gene in negative control of
human tumors. Here we show that Notch1 gene expression and activity are substantially …

Oncogenesis is closely linked to abnormalities in cell differentiation. Notch signaling
provides an important form of intercellular communication involved in cell fate determination …

Cancer development results from deregulated control of stem cell populations and
alterations in their surrounding environment. Notch signaling is an important form of direct …

The Notch1 gene has an important role in mammalian cell-fate decision and tumorigenesis.
Upstream control mechanisms for transcription of this gene are still poorly understood. In a …

The E6 protein of cervical cancer-associated human papillomaviruses (HPVs) is known to
suppress keratinocyte differentiation through unidentified mechanisms. Notch1 is a …

The role of Notch signaling in growth/differentiation control of mammalian epithelial cells is
still poorly defined. We show that keratinocyte‐specific deletion of the Notch1 gene results in …

Notch signaling plays a key role in cell-fate determination and differentiation in different
organisms and cell types. Several reports suggest that Notch signaling may be involved in …

Notch1 is a proto-oncogene in several organs. In the skin, however, Notch1 deletion leads to
tumor formation, suggesting that Notch1 is a" tumor suppressor" within this context. Here we …

Notch is a transmembrane receptor functioning in the determination of cell fate. Abnormal
Notch signaling promotes tumor development, showing either oncogenic or tumor …

Signaling mediated by the Notch receptor governs tissue development during embryonal
organogenesis, while in adult tissues it contributes to maintenance of cellular differentiation …