Osteosarcoma, an aggressive malignant cancer, has a high lung metastasis rate and lacks
therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed …

Proliferation and metastasis are significantly malignant characteristics of human lung
cancer, but the underlying molecular mechanisms are poorly understood. Chromobox 4 …

Polycomb chromobox (CBX) proteins participate in the polycomb repressive complex
(PRC1) that mediates epigenetic gene silencing and endows PRC1 with distinct oncogenic …

Amplification of the chemokines CXCL10 and RANKL has been suggested to promote
osteoclast differentiation and osteolytic bone metastasis, but a function for endogenous …

Deregulation of polycomb proteins influences the development and progression of
hepatocellular carcinoma. Here we show that chromobox 8 (CBX8) expression is increased …

Abstract Background Chromobox 7 (CBX7) is a Polycomb family protein that extends the
lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor …

The CBX7 gene encodes a polycomb group protein that is known to be downregulated in
many types of human cancers, although the role of this protein in carcinogenesis remains …

Breast cancer is the second leading cause of cancer-related death among women
worldwide. Emerging evidence suggests that chromobox homolog 2 (CBX2) is …

Homeobox (HOX) genes encode a family of transcription factors, which play crucial roles in
numerous processes, and their dysregulation is involved in the carcinogenesis of many …

Background Colon cancer (CC) cells can exhibit stemness and expansion capabilities,
which contribute to resistance to conventional chemotherapies. Aberrant expression of …