Aberrant DNA methylation is a common phenomenon in human cancer. The aims of this
study were to investigate the methylation profiles of non-small cell lung cancer (NSCLC) in …

BACKGROUND: We previously identified a number of genes which were methylated
significantly more frequently in the tumor compared to the non-cancerous lung tissues from …

Purpose: The aim of this study was to investigate the prognostic value of hypermethylation of
tumor suppressor genes in patients with non-small cell lung cancer (NSCLC). Experimental …

Purpose To identify the DNA methylation biomarkers for the detection of the stage I non-
small cell lung cancer (NSCLC). Materials and methods The methylated state of p16INK4A …

Background DNA methylation was suggested as the promising biomarker for lung cancer
diagnosis. However, it is a great challenge to search for the optimal combination of …

Background Lung cancer is the leading cause of cancer death in men and women in the
United States and Western Europe. Over 160,000 Americans die of this disease every year …

We used MethyLight assays to analyze DNA methylation status of 27 genes on 49 paired
cancerous and noncancerous tissue samples from non-small cell lung cancer (NSCLC) …

Introduction The recent DNA methylation studies on cancers have revealed the necessity of
profiling an entire human genome and not to restrict the profiling to specific regions of the …

Detection of lung cancer at early stages could potentially increase survival rates. One
promising approach is the application of suitable lung cancer-specific biomarkers to …

Aberrant methylation of promoter CpG islands is known to be a major inactivation
mechanism of tumor suppressor and tumor‐related genes. To determine the …