Increased methylation variation in epigenetic domains across cancer types
Tumor heterogeneity is a major barrier to effective cancer diagnosis and treatment. We
recently identified cancer-specific differentially DNA-methylated regions (cDMRs) in colon …
recently identified cancer-specific differentially DNA-methylated regions (cDMRs) in colon …
[HTML][HTML] Genome-wide methylation analysis of human colon cancer reveals similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
Alterations in DNA methylation (DNAm) in cancer have been known for 25 years, including
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues
G Landan, NM Cohen, Z Mukamel, A Bar… - Nature …, 2012 - nature.com
DNA methylation has been comprehensively profiled in normal and cancer cells, but the
dynamics that form, maintain and reprogram differentially methylated regions remain …
dynamics that form, maintain and reprogram differentially methylated regions remain …
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
Extensive changes in DNA methylation are common in cancer and may contribute to
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …
The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur
in cancer, including hypomethylation of oncogenes and hypermethylation of tumor …
in cancer, including hypomethylation of oncogenes and hypermethylation of tumor …
[HTML][HTML] A DNA methylation map of human cancer at single base-pair resolution
Although single base-pair resolution DNA methylation landscapes for embryonic and
different somatic cell types provided important insights into epigenetic dynamics and cell …
different somatic cell types provided important insights into epigenetic dynamics and cell …
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
S Kalari, GP Pfeifer - Advances in genetics, 2010 - Elsevier
Human cancer genomes are characterized by widespread aberrations in DNA methylation
patterns including DNA hypomethylation of mostly repetitive sequences and …
patterns including DNA hypomethylation of mostly repetitive sequences and …
[HTML][HTML] Pan-cancer patterns of DNA methylation
T Witte, C Plass, C Gerhauser - Genome medicine, 2014 - Springer
The comparison of DNA methylation patterns across cancer types (pan-cancer methylome
analyses) has revealed distinct subgroups of tumors that share similar methylation patterns …
analyses) has revealed distinct subgroups of tumors that share similar methylation patterns …
Cytosine methylation profiling of cancer cell lines
DNA-methylation changes in human cancer are complex and vary between the different
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
A DNA hypermethylation module for the stem/progenitor cell signature of cancer
H Easwaran, SE Johnstone, L Van Neste… - Genome …, 2012 - genome.cshlp.org
Many DNA-hypermethylated cancer genes are occupied by the Polycomb (PcG) repressor
complex in embryonic stem cells (ESCs). Their prevalence in the full spectrum of cancers …
complex in embryonic stem cells (ESCs). Their prevalence in the full spectrum of cancers …