All differential on the splicing front: Host alternative splicing alters the landscape of virus-host conflict

JT Mann, BA Riley, SF Baker - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Alternative RNA splicing is a co-transcriptional process that richly increases proteome
diversity, and is dynamically regulated based on cell species, lineage, and activation state …

Viral modulation of cellular RNA alternative splicing: a new key player in virus–host interactions?

S Boudreault, P Roy, G Lemay… - Wiley Interdisciplinary …, 2019 - Wiley Online Library
Upon viral infection, a tug of war is triggered between host cells and viruses to maintain/gain
control of vital cellular functions, the result of which will ultimately dictate the fate of the host …

[HTML][HTML] Global profiling of the cellular alternative RNA splicing landscape during virus-host interactions

S Boudreault, C Martenon-Brodeur, M Caron… - PloS one, 2016 - journals.plos.org
Alternative splicing (AS) is a central mechanism of genetic regulation which modifies the
sequence of RNA transcripts in higher eukaryotes. AS has been shown to increase both the …

[HTML][HTML] Virus usurps alternative splicing to clear the decks for infection

R Li, S Gao, H Chen, X Zhang, X Yang, J Zhao, Z Wang - Virology Journal, 2023 - Springer
Since invasion, there will be a tug-of-war between host and virus to scramble cellular
resources, for either restraining or facilitating infection. Alternative splicing (AS) is a …

Advances in analyzing virus-induced alterations of host cell splicing

U Ashraf, C Benoit-Pilven, V Lacroix, V Navratil… - Trends in …, 2019 - cell.com
Alteration of host cell splicing is a common feature of many viral infections which is
underappreciated because of the complexity and technical difficulty of studying alternative …

Roles of alternative splicing in infectious diseases: from hosts, pathogens to their interactions

M Lyu, H Lai, Y Wang, Y Zhou, Y Chen, D Wu… - Chinese Medical …, 2023 - mednexus.org
Alternative splicing (AS) is an evolutionarily conserved mechanism that removes introns and
ligates exons to generate mature messenger RNAs (mRNAs), extremely improving the …

Functional and mechanistic interplay of host and viral alternative splicing regulation during influenza infection

MG Thompson, KW Lynch - Cold Spring Harbor Symposia on …, 2019 - symposium.cshlp.org
Alternative splicing is a pervasive gene regulatory mechanism utilized by both mammalian
cells and viruses to expand their genomic coding capacity. The process of splicing and the …

[HTML][HTML] RNA splicing: a new paradigm in host–pathogen interactions

K Chauhan, H Kalam, R Dutt, D Kumar - Journal of molecular biology, 2019 - Elsevier
RNA splicing brings diversity to the eukaryotic proteome. Different spliced variants of a gene
may differ in their structure, function, localization, and stability influencing protein …

[HTML][HTML] Characterization of viral RNA splicing using whole-transcriptome datasets from host species

C Zhou, S Liu, W Song, S Luo, G Meng, C Yang… - Scientific reports, 2018 - nature.com
RNA alternative splicing (AS) is an important post-transcriptional mechanism enabling
single genes to produce multiple proteins. It has been well demonstrated that viruses deploy …

Eukaryotic splicing machinery in the plant–virus battleground

CF Su, D Das, M Muhammad Aslam… - Wiley …, 2023 - Wiley Online Library
Plant virual infections are mainly caused by plant‐virus parasitism which affects ecological
communities. Some viruses are highly pathogen specific that can infect only specific plants …