[HTML][HTML] Staphylococcal and streptococcal superantigens trigger B7/CD28 costimulatory receptor engagement to hyperinduce inflammatory cytokines
A Popugailo, Z Rotfogel, E Supper, D Hillman… - Frontiers in …, 2019 - frontiersin.org
Staphylococcal and streptococcal superantigens are virulence factors that cause toxic shock
by hyperinducing inflammatory cytokines. Effective T-cell activation requires interaction …
by hyperinducing inflammatory cytokines. Effective T-cell activation requires interaction …
[HTML][HTML] Bacterial superantigen toxins induce a lethal cytokine storm by enhancing B7-2/CD28 costimulatory receptor engagement, a critical immune checkpoint
R Kaempfer, A Popugailo, R Levy, G Arad… - Receptors & clinical …, 2017 - ncbi.nlm.nih.gov
Formation of the costimulatory axis between the B7-2 and CD28 coreceptors is critical for T-
cell activation. Superantigens, Gram-positive bacterial virulence factors, cause toxic shock …
cell activation. Superantigens, Gram-positive bacterial virulence factors, cause toxic shock …
Superantigens hyperinduce inflammatory cytokines by enhancing the B7-2/CD28 costimulatory receptor interaction
R Levy, Z Rotfogel, D Hillman… - Proceedings of the …, 2016 - National Acad Sciences
Full T-cell activation requires interaction between the costimulatory receptors B7-2 and
CD28. By binding CD28, bacterial superantigens elicit harmful inflammatory cytokine …
CD28. By binding CD28, bacterial superantigens elicit harmful inflammatory cytokine …
[HTML][HTML] Binding of staphylococcal enterotoxin B (SEB) to B7 receptors triggers TCR-and CD28-mediated inflammatory signals in the absence of MHC class II …
M Kunkl, C Amormino, S Caristi, V Tedeschi… - Frontiers in …, 2021 - frontiersin.org
The inflammatory activity of staphylococcal enterotoxin B (SEB) relies on its capacity to
trigger polyclonal T-cell activation by binding both T-cell receptor (TCR) and costimulatory …
trigger polyclonal T-cell activation by binding both T-cell receptor (TCR) and costimulatory …
[HTML][HTML] Targeting staphylococcal enterotoxin B binding to CD28 as a new strategy for dampening superantigen-mediated intestinal epithelial barrier dysfunctions
C Amormino, E Russo, V Tedeschi, MT Fiorillo… - Frontiers in …, 2024 - frontiersin.org
Staphylococcus aureus is a gram-positive bacterium that may cause intestinal inflammation
by secreting enterotoxins, which commonly cause food-poisoning and gastrointestinal …
by secreting enterotoxins, which commonly cause food-poisoning and gastrointestinal …
[HTML][HTML] Bacterial superantigen toxins, CD28, and drug development
R Kaempfer - Toxins, 2018 - mdpi.com
During severe bacterial infections, death and disease are often caused by an overly strong
immune response of the human host. Acute toxic shock is induced by superantigen toxins, a …
immune response of the human host. Acute toxic shock is induced by superantigen toxins, a …
[HTML][HTML] The homodimer interfaces of costimulatory receptors B7 and CD28 control their engagement and pro-inflammatory signaling
A Popugailo, Z Rotfogel, M Levy, O Turgeman… - Journal of Biomedical …, 2023 - Springer
Background The inflammatory response is indispensable for protective immunity, yet
microbial pathogens often trigger an excessive response,'cytokine storm', harmful to the …
microbial pathogens often trigger an excessive response,'cytokine storm', harmful to the …
[HTML][HTML] Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells
M Kunkl, C Amormino, F Spallotta, S Caristi… - Frontiers in …, 2023 - frontiersin.org
Staphylococcus aureu s superantigens (SAgs) such as staphylococcal enterotoxin A (SEA)
and B (SEB) are potent toxins stimulating T cells to produce high levels of inflammatory …
and B (SEB) are potent toxins stimulating T cells to produce high levels of inflammatory …
[HTML][HTML] CD28: direct and critical receptor for superantigen toxins
R Kaempfer, G Arad, R Levy, D Hillman, I Nasie… - Toxins, 2013 - mdpi.com
Every adaptive immune response requires costimulation through the B7/CD28 axis, with
CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and …
CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and …
Costimulation regulates the kinetics of interleukin‐2 response to bacterial superantigens
E Muraille, S Devos, K Thielemans, J Urbain… - …, 1996 - Wiley Online Library
The aim of this study was to investigate the mechanisms by which B7‐related costimulatory
molecules (CD80, CD86) increase T‐cell responsiveness to extracellular ligands. As a …
molecules (CD80, CD86) increase T‐cell responsiveness to extracellular ligands. As a …