Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

Neuropathic pain is a highly debilitating chronic pain state that is a consequence of nerve
injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma …

Current deficiency in our understanding of acute-to-chronic pain transition remains a hurdle
for developing effective treatments against chronic pain. Whereas neurocentric mechanisms …

Introduction: Current pharmacotherapeutics for neuropathic pain offer only symptomatic
relief without treating the underlying pathophysiology. Additionally, they are associated with …

Microglia are regarded as macrophages in the central nervous system (CNS) and play an
important role in neuroinflammation in the CNS. Microglial activation has been strongly …

Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …

Neuropathic pain is a common and severely disabling state that affects millions of people
worldwide. Such pain can be experienced after nerve injury or as part of diseases that affect …

In contrast to physiological pain, pathological pain is not dependent on the presence of
tissue‐damaging stimuli. One type of pathological pain—neuropathic pain—is often a …

Damage to the nervous system can cause neuropathic pain, which is in general poorly
treated and involves mechanisms that are incompletely known. Currently available animal …

A high-intensity potentially tissue-injuring stimulus generates a homotopic response to
escape the stimulus and is associated with an affective phenotype considered to represent …