The amygdala is a core component of neural circuits that mediate processing of emotional,
particularly anxiety and fear-related stimuli across species. In addition, the nuclear complex …

The basolateral nuclear complex of the amygdala (BLC) receives a dense serotonergic
innervation that appears to play a critical role in the regulation of mood and anxiety …

The serotonin system is strongly implicated in the pathophysiology and therapeutic
alleviation of stress-related disorders such as anxiety and depression. Serotonergic …

Over 20 years ago, Deakin and Graeff hypothesized about the role of different serotonergic
pathways in controlling the behavioral and physiologic responses to aversive stimuli, and …

Brain systems that promote the maintenance of homeostasis in face of stress have
significant adaptive value. A growing body of work across species demonstrates a critical …

The wide use of serotonin reuptake inhibitors and serotonin receptor agonists in anxiety
disorders has suggested a key role for the modulatory neurotransmitter in anxiety. However …

Reports of gene–environment interactions (GxE) between the serotonin transporter gene
and stress on risk of depression have generated both excitement and controversy. The …

Whole cell patch-clamp recordings were obtained from projection neurons and interneurons
of the rat basolateral amygdala (BLA) to understand local network interactions in …

The amygdala is considered a key center in managing emotional information and its
dysfunction is at the base of disorders ranging through anxiety, depression, PTSD and …

Chronic stress induces anhedonia in susceptible but not resilient individuals, a
phenomenon observed in humans as well as animal models, but the molecular mechanisms …