Immunomodulation by vasoactive intestinal peptide is associated with increased survival and growth of Salmonella Typhimurium in mice

B Askar, J Higgins, P Barrow, N Foster - Cytokine, 2020 - Elsevier
Studies have shown that administration of vasoactive intestinal peptide (VIP) in mice
rescues them from lethal endotoxaemia and that this is correlated with decreased …

Vasoactive intestinal peptide (VIP) differentially affects inflammatory immune responses in human monocytes infected with viable Salmonella or stimulated with LPS

B Askar, H Ibrahim, P Barrow, N Foster - Peptides, 2015 - Elsevier
We compared the effect of VIP on human blood monocytes infected with Salmonella
typhimurium 4/74 or stimulated with LPS. VIP (10− 7 M) increased monocyte viability by 24 …

Inhibition of IFN-γ-stimulated proinflammatory cytokines by vasoactive intestinal peptide (VIP) correlates with increased survival of Salmonella enterica serovar …

N Foster, SD Hulme, PA Barrow - Journal of interferon & cytokine …, 2005 - liebertpub.com
Vasoactive intestinal peptide (VIP) is a novel Th2 cytokine that has been shown previously
to rescue rats and mice from the lethal effect of bacterial lipopolysaccharide (LPS). We report …

Vasoactive intestinal peptide (VIP) prevents killing of virulent and phoP mutant Salmonella typhimurium by inhibiting IFN-γ stimulated NADPH oxidative pathways in …

N Foster, SD Hulme, PA Barrow - Cytokine, 2006 - Elsevier
Vasoactive intestinal peptide is an immunomodulator with great potential in the treatment of
inflammatory pathology. In this study, we have examined the effect of VIP on the growth …

Anti‐inflammatory properties of the type 1 and type 2 vasoactive intestinal peptide receptors: role in lethal endotoxic shock

M Delgado, RP Gomariz, C Martinez… - European journal of …, 2000 - Wiley Online Library
Vasoactive intestinal peptide (VIP) is a neuropeptide that can modulate several immune
aspects. Previous reports showed that VIP attenuates the deleterious consequences of …

Dysregulation of JAK/STAT genes by vasoactive intestinal peptide (VIP) in Salmonella-infected monocytes may inhibit its therapeutic potential in human sepsis

H Ibrahim, B Askar, P Barrow, N Foster - Cytokine, 2018 - Elsevier
Murine/LPS models of Gram negative sepsis indicate that vasoactive intestinal peptide (VIP)
has therapeutic potential. We investigated the unknown effect of VIP on JAK/STAT proteins …

VIP deficient mice exhibit resistance to lipopolysaccharide induced endotoxemia with an intrinsic defect in proinflammatory cellular responses

C Abad, YV Tan, G Cheung-Lau, H Nobuta… - PLoS …, 2012 - journals.plos.org
Vasoactive intestinal peptide (VIP) is a pleiotropic neuropeptide with immunomodulatory
properties. The administration of this peptide has been shown to have beneficial effects in …

Immunomodulation of innate immune responses by vasoactive intestinal peptide (VIP): its therapeutic potential in inflammatory disease

SGR Smalley, PA Barrow… - Clinical & Experimental …, 2009 - academic.oup.com
Since the late 1970s a number of laboratories have studied the role of vasoactive intestinal
peptide (VIP) in inflammation and immunity. These studies have highlighted the dramatic …

Role of vasoactive intestinal peptide in inflammation and autoimmunity.

E Gonzalez-Rey, M Delgado - Current opinion in investigational …, 2005 - europepmc.org
Vasoactive intestinal peptide (VIP), a peptide produced by immune cells, exerts a wide
spectrum of immunological functions that control the homeostasis of the immune system. In …

Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases

M Delgado, C Abad, C Martinez, M Juarranz… - Journal of molecular …, 2002 - Springer
Vasoactive intestinal peptide (VIP), a neuropeptide that is produced by lymphoid as well as
neural cells, exerts a wide spectrum of immunological functions, controlling the homeostasis …