Dynamical brain state transitions are critical for flexible working memory but the network
mechanisms are incompletely understood. Here, we show that working memory …

Schizophrenia is increasingly recognized as a disorder of distributed neural dynamics, but
the molecular and genetic contributions are poorly understood. Recent work highlights a …

Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons
to task-relevant stimuli. Enabled by simultaneous positron emission tomography–magnetic …

The neural mechanisms behind cognitive deficits in schizophrenia still remain unclear.
Functional neuroimaging studies on working memory (WM) yielded inconsistent results …

Excitation–inhibition balance (E/I balance) is a fundamental property of cortical
microcircuitry. Disruption of E/I balance in prefrontal cortex is hypothesized to underlie …

BACKGROUND: Working memory studies in schizophrenia (SZ), using functional magnetic
resonance imaging (fMRI) and univariate analyses, have led to observations of hypo-or …

Deficits in working memory (WM) are a consistent neurocognitive marker for schizophrenia.
Previous studies have suggested that WM is the product of coordinated activity in distributed …

The mediodorsal thalamus (MD) shares reciprocal connectivity with the prefrontal cortex
(PFC), and decreased MD–PFC connectivity is observed in schizophrenia patients. Patients …

Cognitive deficits are critical determinants of schizophrenia morbidity. In this review, we offer
a mechanistic perspective regarding schizophrenia-related changes observed in prefrontal …

Background Numerous neuroimaging studies report abnormal regional brain activity during
working memory performance in schizophrenia, but few have examined brain network …