The thymus has the ability to regenerate from acute injury caused by radiation, infection, and
stressors. In addition to thymocytes, thymic epithelial cells in the medulla (mTECs), which …

Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by
mediating negative selection of autoreactive T cells through the collective expression of the …

The thymus is the organ dedicated to the generation of T cells, which are key effector cells in
immune clearance of pathogens and tumours. However, T cells can also react to our own …

Thymic epithelial cells (TECs) make up the thymic microenvironments that support the
generation of a functionally competent and self-tolerant T-cell repertoire. Cortical (c) TECs …

Thymic epithelial cells in the medulla (mTECs) play a critical role in enforcing central
tolerance through expression and presentation of tissue-specific antigens (TSAs) and …

Autoimmune regulator+ (Aire) medullary thymic epithelial cells (mTECs) play a critical role in
tolerance induction. Several studies demonstrated that Aire+ mTECs differentiate further into …

Thymic aging precedes that of other organs and is initiated by the gradual loss of thymic
epithelial cells (TECs). Based on in vitro culture and transplantation assays, recent studies …

Medullary thymic epithelial cells (mTECs) are essential for the establishment of self-
tolerance in T cells. Promiscuous gene expression by a subpopulation of mTECs regulated …

Medullary thymic epithelial cells (mTECs) are critical for self-tolerance induction in T cells via
promiscuous expression of tissue-specific antigens (TSAs), which are controlled by the …

Degeneration of the thymic epithelium is believed to be the primary cause of age-associated
thymic involution. In order to investigate the molecular events during the early phase of …