[HTML][HTML] Mitochondrial Modulators: the defender

E Makinde, L Ma, GD Mellick, Y Feng - Biomolecules, 2023 - mdpi.com
Mitochondria are widely considered the “power hub” of the cell because of their pivotal roles
in energy metabolism and oxidative phosphorylation. However, beyond the production of …

[HTML][HTML] Pharmacological advances in mitochondrial therapy

A Singh, D Faccenda, M Campanella - EBioMedicine, 2021 - thelancet.com
Mitochondria play a vital role in cellular metabolism and are central mediator of intracellular
signalling, cell differentiation, morphogenesis and demise. An increasingly higher number of …

Mitochondria-targeted agents: mitochondriotropics, mitochondriotoxics, and mitocans

D Guzman-Villanueva, V Weissig - Pharmacology of Mitochondria, 2017 - Springer
Mitochondria, the powerhouse of the cell, have been known for many years for their central
role in the energy metabolism; however, extensive progress has been made and to date …

Mitochondrial drug targets in neurodegenerative diseases

J Lee - Bioorganic & Medicinal Chemistry Letters, 2016 - Elsevier
Growing evidence suggests that mitochondrial dysfunction is the main culprit in
neurodegenerative diseases. Given the fact that mitochondria participate in diverse cellular …

[HTML][HTML] Mitochondrial pharmacology

RAJ Smith, RC Hartley, HM Cocheme… - Trends in pharmacological …, 2012 - cell.com
Mitochondria are being recognized as key factors in many unexpected areas of biomedical
science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it …

Mitochondrial pharmacology: its future is now

HH Szeto, LP James, AJ Atkinson - Clinical Pharmacology & …, 2014 - Wiley Online Library
Mitochondrial medicine is an evolving discipline whose importance derives from the central
function of mitochondria in adenosine triphosphate (ATP) production, generation of reactive …

Repairing mitochondrial dysfunction in disease

V Sorrentino, KJ Menzies… - Annual review of …, 2018 - annualreviews.org
Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …

[HTML][HTML] Natural products in regulating mitochondrial dysfunction

C Xie, L Ma, X Wang, X Xiong - Frontiers in Pharmacology, 2023 - frontiersin.org
Mitochondria plays a central role in energy production for all multicellular eukaryotes by
synthesizing ATP and maintaining metabolic homeostasis. Actually, these fantastic …

Potential therapeutic benefits of strategies directed to mitochondria

AKS Camara, EJ Lesnefsky… - Antioxidants & redox …, 2010 - liebertpub.com
The mitochondrion is the most important organelle in determining continued cell survival
and cell death. Mitochondrial dysfunction leads to many human maladies, including …

Mitochondria-targeted drugs

RA Zinovkin, AA Zamyatnin - Current Molecular Pharmacology, 2019 - ingentaconnect.com
Background: Targeting of drugs to the subcellular compartments represents one of the
modern trends in molecular pharmacology. The approach for targeting mitochondria was …