[HTML][HTML] Mitochondrial Modulators: the defender
Mitochondria are widely considered the “power hub” of the cell because of their pivotal roles
in energy metabolism and oxidative phosphorylation. However, beyond the production of …
in energy metabolism and oxidative phosphorylation. However, beyond the production of …
[HTML][HTML] Pharmacological advances in mitochondrial therapy
A Singh, D Faccenda, M Campanella - EBioMedicine, 2021 - thelancet.com
Mitochondria play a vital role in cellular metabolism and are central mediator of intracellular
signalling, cell differentiation, morphogenesis and demise. An increasingly higher number of …
signalling, cell differentiation, morphogenesis and demise. An increasingly higher number of …
Mitochondria-targeted agents: mitochondriotropics, mitochondriotoxics, and mitocans
D Guzman-Villanueva, V Weissig - Pharmacology of Mitochondria, 2017 - Springer
Mitochondria, the powerhouse of the cell, have been known for many years for their central
role in the energy metabolism; however, extensive progress has been made and to date …
role in the energy metabolism; however, extensive progress has been made and to date …
Mitochondrial drug targets in neurodegenerative diseases
J Lee - Bioorganic & Medicinal Chemistry Letters, 2016 - Elsevier
Growing evidence suggests that mitochondrial dysfunction is the main culprit in
neurodegenerative diseases. Given the fact that mitochondria participate in diverse cellular …
neurodegenerative diseases. Given the fact that mitochondria participate in diverse cellular …
[HTML][HTML] Mitochondrial pharmacology
Mitochondria are being recognized as key factors in many unexpected areas of biomedical
science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it …
science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it …
Mitochondrial pharmacology: its future is now
Mitochondrial medicine is an evolving discipline whose importance derives from the central
function of mitochondria in adenosine triphosphate (ATP) production, generation of reactive …
function of mitochondria in adenosine triphosphate (ATP) production, generation of reactive …
Repairing mitochondrial dysfunction in disease
V Sorrentino, KJ Menzies… - Annual review of …, 2018 - annualreviews.org
Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …
[HTML][HTML] Natural products in regulating mitochondrial dysfunction
C Xie, L Ma, X Wang, X Xiong - Frontiers in Pharmacology, 2023 - frontiersin.org
Mitochondria plays a central role in energy production for all multicellular eukaryotes by
synthesizing ATP and maintaining metabolic homeostasis. Actually, these fantastic …
synthesizing ATP and maintaining metabolic homeostasis. Actually, these fantastic …
Potential therapeutic benefits of strategies directed to mitochondria
AKS Camara, EJ Lesnefsky… - Antioxidants & redox …, 2010 - liebertpub.com
The mitochondrion is the most important organelle in determining continued cell survival
and cell death. Mitochondrial dysfunction leads to many human maladies, including …
and cell death. Mitochondrial dysfunction leads to many human maladies, including …
Mitochondria-targeted drugs
RA Zinovkin, AA Zamyatnin - Current Molecular Pharmacology, 2019 - ingentaconnect.com
Background: Targeting of drugs to the subcellular compartments represents one of the
modern trends in molecular pharmacology. The approach for targeting mitochondria was …
modern trends in molecular pharmacology. The approach for targeting mitochondria was …