1, 25-dihydroxyvitamin D 3 inhibits renal interstitial myofibroblast activation by inducing
hepatocyte growth factor expression. Background Vitamin D and its metabolites play an …

Several studies indicate a relationship between hypovitaminosis D, survival, vascular
calcification and inflammation. In addition to its central role in the regulation of bone mineral …

Vitamin D, especially its most active metabolite 1, 25-dihydroxyvitamin D3 or calcitriol, is
essential in regulating a wide variety of biologic processes, such as calcium homeostasis …

Analogs of vitamin D attenuate renal injury in several models of kidney disease, but the
mechanism underlying this renoprotective effect is unknown. To address the role of the …

Atherosclerosis is a complex process characterized by an increase in the wall thickness
owing to the accumulation of cells and extracellular matrix between the endothelium and the …

Kidney fibrosis is the common final pathway of chronic kidney diseases (CKD). It is
characterized by myofibroblast formation, inflammation, and epithelial architecture damage …

Both peritubular inflammation and tubular epithelial-to-mesenchymal transition (EMT) are
critical events during the pathogenesis of renal fibrosis. However, the relationship between …

Renal fibrosis, the characteristic feature of progressive chronic kidney disease, is associated
with unremitting renal inflammation. Although it is reported that 1, 25-dihydroxyvitamin D3 (1 …

TGF-β1 expression closely associates with activation and conversion of fibroblasts to a
myofibroblast phenotype and synthesis of an alternatively spliced cellular fibronectin variant …

Tubulointerstitial fibrosis (TIF) is one of the major problems in nephrology because
satisfactory therapeutic strategies have not been established. Here, we demonstrate that …