Endogenous opioidergic dysregulation of pain in fibromyalgia: a PET and fMRI study
Endogenous opioid system dysfunction potentially contributes to chronic pain in
fibromyalgia (FM), but it is unknown if this dysfunction is related to established …
fibromyalgia (FM), but it is unknown if this dysfunction is related to established …
Decreased central μ-opioid receptor availability in fibromyalgia
The underlying neurophysiology of acute pain is fairly well characterized, whereas the
central mechanisms operative in chronic pain states are less well understood. Fibromyalgia …
central mechanisms operative in chronic pain states are less well understood. Fibromyalgia …
Patients with fibromyalgia display less functional connectivity in the brain's pain inhibitory network
Background: There is evidence for augmented processing of pain and impaired
endogenous pain inhibition in Fibromyalgia syndrome (FM). In order to fully understand the …
endogenous pain inhibition in Fibromyalgia syndrome (FM). In order to fully understand the …
Altered fMRI resting‐state connectivity in individuals with fibromyalgia on acute pain stimulation
E Ichesco, T Puiu, JP Hampson… - … journal of pain, 2016 - Wiley Online Library
Background Fibromyalgia is a chronic widespread pain condition, with patients commonly
reporting other symptoms such as sleep difficulties, memory complaints and fatigue. The use …
reporting other symptoms such as sleep difficulties, memory complaints and fatigue. The use …
Breaking down the barriers: fMRI applications in pain, analgesia and analgesics
D Borsook, LR Becerra - Molecular pain, 2006 - journals.sagepub.com
This review summarizes functional magnetic resonance imaging (fMRI) findings that have
informed our current understanding of pain, analgesia and related phenomena, and …
informed our current understanding of pain, analgesia and related phenomena, and …
[HTML][HTML] Altered pain in the brainstem and spinal cord of fibromyalgia patients during the anticipation and experience of experimental pain
Chronic pain associated with fibromyalgia (FM) affects a large portion of the population but
the underlying mechanisms leading to this altered pain are still poorly understood. Evidence …
the underlying mechanisms leading to this altered pain are still poorly understood. Evidence …
Altered brain activity during pain processing in fibromyalgia
M Burgmer, E Pogatzki-Zahn, M Gaubitz, E Wessoleck… - Neuroimage, 2009 - Elsevier
Fibromyalgia syndrome (FMS) is characterized by widespread pain. Studies with functional
neuroimaging support the hypothesis of central pain augmentation in FMS. We tested this in …
neuroimaging support the hypothesis of central pain augmentation in FMS. We tested this in …
[HTML][HTML] Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI
Background Nociceptive stimuli may evoke brain responses longer than the stimulus
duration often partially detected by conventional neuroimaging. Fibromyalgia patients …
duration often partially detected by conventional neuroimaging. Fibromyalgia patients …
Fibromyalgia is associated with decreased connectivity between pain-and sensorimotor brain areas
P Flodin, S Martinsen, M Löfgren… - Brain …, 2014 - liebertpub.com
Fibromyalgia (FM) is a syndrome characterized by chronic pain without known peripheral
causes. Previously, we have reported dysfunctional pain inhibitory mechanisms for FM …
causes. Previously, we have reported dysfunctional pain inhibitory mechanisms for FM …
[HTML][HTML] Painful after-sensations in fibromyalgia are linked to catastrophizing and differences in brain response in the medial temporal lobe
Fibromyalgia (FM) is a complex syndrome characterized by chronic widespread pain,
hyperalgesia, and other disabling symptoms. Although the brain response to experimental …
hyperalgesia, and other disabling symptoms. Although the brain response to experimental …