A relationship appears to exist between dysfunction of brain histamine (HA) and various
neuropsychiatric brain disorders. The possible involvement of brain HA in neuropathology …

The potential contributions of the brain histaminergic system in neurodegenerative diseases,
and the possiblity of histamine-targeting treatments is attracting considerable interests. The …

Histamine and its receptors were first described as part of immune and gastrointestinal
systems, but their presence in the central nervous system and importance in behavior are …

The G i/o protein-coupled histamine H 3 receptor is distributed throughout the central
nervous system including areas like cerebral cortex, hippocampus and striatum with the …

Histamine and its receptors in the nervous system received recognition late in comparison to
the other aminergic transmitters, after the detection of histaminergic neurons in the posterior …

Histamine H3 receptor (H3R) antagonists/inverse agonists possess potential to treat diverse
disease states of the central nervous system (CNS). Cognitive dysfunction and motor …

Histamine H 3 receptor pharmacology, functions and biochemistry are far from being fully
understood; however, progress is being made. Activation of this G i/G o-protein-coupled …

Brain histamine is involved in a wide range of physiological functions such as regulation of
the sleep-wake cycle, arousal, cognition, and memory mainly through interactions with …

Histamine has long been known to trigger allergic reactions and gastric acid secretion.
However, it was later discovered that, in the brain, histamine regulates basic homeostatic …

The role of histamine in the central nervous system (CNS) is currently an area of great
interest. There are two major sources of amine in the human brain, namely mast cells and …