Ewing sarcoma is an aggressive paediatric cancer of the bone and soft tissue. It results from
a chromosomal translocation, predominantly t (11; 22)(q24: q12), that fuses the N-terminal …

The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer
Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the …

Transcription factors (TFs) are frequently mutated in cancer. Paediatric cancers exhibit few
mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which …

Many sarcomas and leukemias carry nonrandom chromosomal translocations encoding
tumor-specific mutant fusion transcription factors that are essential to their molecular …

Ewing sarcoma is an aggressive bone malignancy that affect children and young adults.
Ewing sarcoma is the second most common primary bone malignancy in pediatric patients …

Deciphering the ways in which somatic mutations and germline susceptibility variants
cooperate to promote cancer is challenging. Ewing sarcoma is characterized by fusions …

There is a great need to develop novel approaches to target oncogenic transcription factors
with small molecules. Ewing sarcoma is emblematic of this need, as it depends on the …

Summary EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a
cascade of signaling events leading to cell transformation. However, it remains elusive how …

Developmental tumors in children and young adults carry few genetic alterations, yet they
have diverse clinical presentation. Focusing on Ewing sarcoma, we sought to establish the …

Targeted therapy for cancer, which is specifically directed toward the cancer without any
potential for effects outside of controlling the tumor, is a gold standard for treatment. Ewing's …