(1) Background: Milnacipran is a typical serotonin–norepinephrine reuptake inhibitor and
has been shown to have analgesic effects in several pain models. However, its …

Paclitaxel is widely used in cancer chemotherapy for the treatment of solid tumors, but it
frequently causes peripheral neuropathy. Milnacipran, a serotonin/noradrenaline reuptake …

We investigated whether milnacipran, a serotonin–noradrenaline reuptake inhibitor, would
have therapeutic effect on oxaliplatin-induced mechanical allodynia in mice. A single …

Vincristine is an anticancer drug used to treat a variety of cancer types, but it frequently
causes peripheral neuropathy. Neuropathic pain is often associated with the appearance of …

Oxaliplatin is a platinum-based chemotherapy drug characterized by the development of
acute and chronic peripheral neuropathies. Mexiletine, an orally available Na+-channel …

Cisplatin is a widely used platinum-derived antineoplastic agent that frequently results in
peripheral neuropathy. Therapeutic strategies for neuropathic pain are limited and …

Background Donepezil, a cholinesterase inhibitor approved in Alzheimer's disease, has
demonstrated analgesic and preventive effects in animal models of oxaliplatin-induced …

Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose limiting side-effect of
several commonly used chemotherapeutic agents (such as cisplatin) that profoundly impairs …

Background: Chemotherapy-induced neuropathic pain is difficult to treat. Pentoxifylline
inhibits the production of inflammatory cytokines including tumor necrosis factor α (TNF-α) …

Background: Milnacipran is one of the classes of drugs that are serotonin and
norepinephrine reuptake inhibitors (SNRIs). It is a promising drug for the treatment of …